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510122 Sigma-Aldrich

3-(Trifluoromethoxy)phenylboronic acid

≥95%

Synonym: 3-Trifluoromethoxybenzeneboronic acid

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Properties

Related Categories Aryl Boronic Acids, Boronic Acids, Boronic Acids and Derivatives, Chemical Synthesis, Monosubstituted Aryl Boronic Acids,
InChI Key   UWDFWVLAHRQSKK-UHFFFAOYSA-N
assay   ≥95%
mp   84-89 °C (lit.)

Description

Application

Precursor commonly used in the synthesis of biologically active compounds including:
• Multisubstituted purines for use as P2X7 antagonists in the treatment of pain
• Heteroaryl substituted tetrahydropyrroloijquinolinone derivatives as aldosterone synthase inhibitors
• Fluorohydroquinolineethanol as a CETP inhibitor
• Biaryl amides with muscarinic acetylcholine receptor subtype M1 agonist activity
• C2-aryl pyrrolobenzodiasepine antitumor agents
• Piperazine-bisamide for obesity treatments

Packaging

5 g in glass bottle

Other Notes

Contains varying amounts of anhydride

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Arylboronic Acids

We are pleased to present its complete selection of arylboronic acids, the building blocks of the Suzuki coupling experiment. Most arylboronic acids readily undergo dehydration reactions to give a cy...
ChemFiles 2001, 1.1, 5.
Keywords: Building blocks, Coupling reactions, Dehydration reaction, Suzuki coupling

Boronic Acids - ChemFiles 2007

Most boronic acids readily undergo dehydration reactions to give a cyclic (trimer) anhydride. Our selection of boronic acids may contain varying amounts of this cyclic anhydride. Fortunately, the aci...
ChemFiles 2007, 7.7, 3.
Keywords: Coupling reactions, Dehydration reaction, Suzuki coupling

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