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516732 Sigma-Aldrich

2-Mercaptoethanol

Synonym: β-Mercaptoethanol, 2-Hydroxyethylmercaptan, 2ME, BME, Thioethylene glycol

  • CAS Number 60-24-2

  • Linear Formula HSCH2CH2OH

  • Molecular Weight 78.13

  •  Beilstein/REAXYS Number 773648

  •  EC Number 200-464-6

  •  MDL number MFCD00004890

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Properties

vapor density   2.69 (vs air)
vapor pressure   1 mmHg ( 20 °C)
InChI Key   DGVVWUTYPXICAM-UHFFFAOYSA-N
expl. lim.   18 %
concentration   14.3 M (pure liquid)
refractive index   n20/D 1.500 (lit.)
bp   157 °C (lit.)
density   1.114 g/mL at 25 °C (lit.)

Description

Application

BME is suitable for reducing protein disulfide bonds prior to polyacrylamide gel electrophoresis and is usually included in a sample buffer for SDS-PAGE at a concentration of 5%. Cleaving intermolecular (between subunits) disulfide bonds allows the subunits of a protein to separate independently on SDS-PAGE. Cleaving intramolecular (within subunit) disulfide bonds allows the subunits to become completely denatured so that each peptide migrates according to its chain length with no influence due to secondary structure.

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Product of Arkema

Safety & Documentation

Safety Information

Signal word 
Danger
Target organs 
Heart, Liver
RIDADR 
UN 2966 6.1 / PGII
WGK Germany 
3
RTECS 
KL5600000
Flash Point(F) 
165.2 °F
Flash Point(C) 
74 °C
Protocols & Articles
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M6250 2-Mercaptoethanol, ≥99.0%

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