524972 Sigma-Aldrich

Diethyl phthalate


  • CAS Number 84-66-2

  • Linear Formula C6H4-1,2-(CO2C2H5)2

  • Molecular Weight 222.24

  •  Beilstein/REAXYS Number 1912500

  •  EC Number 201-550-6

  •  MDL number MFCD00009111

  •  PubChem Substance ID 24874455

  •  NACRES NA.22



Related Categories Building Blocks, C12 to C63, Carbonyl Compounds, Chemical Synthesis, Esters,
vapor density   7.66 (vs air)
vapor pressure   1 mmHg ( 100 °C)
assay   99.5%
form   liquid
autoignition temp.   854 °F
expl. lim.   0.75 %, 187 °F
impurities   ≤0.18% water
color   APHA: ≤15
refractive index   n20/D 1.502 (lit.)
bp   298-299 °C (lit.)
mp   −3 °C (lit.)
density   1.12 g/mL at 25 °C (lit.)
storage temp.   room temp
SMILES string   CCOC(=O)c1ccccc1C(=O)OCC
InChI   1S/C12H14O4/c1-3-15-11(13)9-7-5-6-8-10(9)12(14)16-4-2/h5-8H,3-4H2,1-2H3


General description

Diethyl phthalate (DEP) is a phthalic anhydride ester (PAE) that is commonly used as a solvent in cosmetics and also as a plasticizer.


Diethyl phthalate can be used as a solvent for the antimony reduction of aluminum chloride-phosphorus trichloride-alkyl chloride complexes to form the corresponding alkylphosphonous dichlorides. It can undergo condensation with o-phenylenediamine in the presence of sodium hydride to form dibenzo (b,f)(1,4)diazocine-6,11(5H, 12H)-dione.


1, 4 L in poly bottle

100 mL in poly bottle

5 mL in glass bottle

Other Notes


Safety & Documentation

Safety Information

Personal Protective Equipment 
UN 3082 9 / PGIII
WGK Germany 
Flash Point(F) 
338.0 °F - closed cup
Flash Point(C) 
170 °C - closed cup


Certificate of Analysis (COA)

Please Enter a Lot Number

Certificate of Origin (COO)

Please Enter a Lot Number

Frequently Asked Questions

How does the storage temperature relate to shipping conditions?
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
I want to use Product 524972, Diethyl phthalate in cell culture or tissue culture. In what solvent can I dilute diethyl phthlate?
Product 524972, Diethyl phthalate,is soluble in ethanol to 0.1 M. Lee, S.-M., et al., Dibutyl Phthalate Biodegradation by the White Rot Fungus, Polyporus brumalis. Biotechnology and Bioengineering,97(6),1516-1522 (2007).
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
Show more questions
Protocols & Articles
Peer-Reviewed Papers


Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?