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526797 Sigma-Aldrich

Cyclopropylmagnesium bromide solution

0.5 M in THF

  • CAS Number 23719-80-4

  • Empirical Formula (Hill Notation) C3H5BrMg

  • Molecular Weight 145.28

  •  MDL number MFCD00672094

  •  PubChem Substance ID 24874579

  •  NACRES NA.22

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Properties

Related Categories Alkyl, Aryl and Alkenyl - Grignard reagent, Chemical Synthesis, Grignard Reagents, Organometallic Reagents
InChI Key   QUPLLJGAJVXXBW-UHFFFAOYSA-M
concentration   0.5 M in THF
bp   65 °C
density   0.968 g/mL at 25 °C
storage temp.   2-8°C

Description

Application

Cyclopropylmagnesium bromide solution has been used in Grignard reaction that finds application as the key step in the preparation of aminopropylindenes, a chemotype of oxidosqualene cyclase (OSC) inhibitors from Grundmann′s ketone. It can react with trimethylborate to form cyclopropylboronic acid, which can undergo Suzuki-type coupling reactions with different aryl, and heteroaryl bromides to form the cyclopropyl adducts.

Packaging

100, 800 mL in Sure/Seal™

Safety & Documentation

Safety Information

Signal word 
Danger
Hazard statements 
Supplemental Hazard Statements 
May form explosive peroxides.
RIDADR 
UN 3399BC 4.3(3) / PGII
WGK Germany 
3
Flash Point(F) 
1.4 °F
Flash Point(C) 
-17 °C

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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