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531413 Sigma-Aldrich

2,2-Difluoro-2-(fluorosulfonyl)acetic acid

97%

Synonym: (Fluorosulfonyl)difluoroacetic acid

  • CAS Number 1717-59-5

  • Linear Formula FSO2CF2CO2H

  • Molecular Weight 178.09

  •  MDL number MFCD01320807

  •  PubChem Substance ID 24877815

  •  NACRES NA.22

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Properties

Related Categories Alkyl Fluorinated Building Blocks, Bi-Functional Sulfonyl Fluorides, Building Blocks, Building Blocks for SuFEx: The Next Click Reaction, Chemical Synthesis,
Quality Level   100
assay   97%
reaction suitability   reaction type: click chemistry
refractive index   n20/D 1.36 (lit.)
bp   153 °C (lit.)
density   1.723 g/mL at 25 °C (lit.)
SMILES string   OC(=O)C(F)(F)S(F)(=O)=O
InChI   1S/C2HF3O4S/c3-2(4,1(6)7)10(5,8)9/h(H,6,7)
InChI key   VYDQUABHDFWIIX-UHFFFAOYSA-N

Description

General description

2,2-Difluoro-2-(fluorosulfonyl)acetic acid reagent is employed as a difluorocarbene source for difluoromethylation of phenolic hydroxyl groups.

Application

2,2-Difluoro-2-(fluorosulfonyl)acetic acid may be used in the following processes:
• Preparation of 1-difluoromethyl-2-oxo-1,2-dihydropyridine analogs by reacting with the corresponding 2-chloropyridines.
• Prepration of silyl fluorosulfonyldifluoroacetate as new highly efficient difluorocarbene reagent for cyclopropanation of alkenes.
• Regio- and stereoselective free radical fluoroalkylation of terminal alkenes and alkynes with iododifluoromethanesulfonamides.

Packaging

25 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2927 8(6.1) / PGI
WGK Germany 
WGK 3
Flash Point(F) 
230.0 °F - closed cup
Flash Point(C) 
110 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Meet Synthia - Retrosynthesis Sofware
Protocols & Articles
Peer-Reviewed Papers
15

References

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