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532703 Sigma-Aldrich

1-Bromo-4-chloro-2-fluorobenzene

98%

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Properties

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InChI Key   FPNVMCMDWZNTEU-UHFFFAOYSA-N
assay   98%
refractive index   n20/D 1.556(lit.)
bp   91-92 °C/20 mmHg(lit.)
density   1.678 g/mL at 25 °C(lit.)

Description

Packaging

25 g in glass bottle

Application

1-Bromo-4-chloro-2-fluorobenzene may be used in the preparation of benzonorbornadiene derivative. It may also be used as a starting material in the multi-step synthesis of AZD3264, an IKK2 (inhibitor of nuclear factor κ-B kinase-2) inhibitor.

General description

1-Bromo-4-chloro-2-fluorobenzene is a polyhalo substituted benzene. It undergoes Suzuki coupling with 2-cyanoarylboronic esters to form the corresponding biphenyls. These biphenyls are the precursors for synthesizing 6-substituted phenanthridines.† The enthalpy of vaporization at boiling point (467.15K) of 1-bromo-4-chloro-2-fluorobenzene is 40.737kjoule/mol.{4}

Safety & Documentation

Safety Information

WGK Germany 
3
Flash Point(F) 
197.6 °F
Flash Point(C) 
92 °C

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Protocols & Articles
Peer-Reviewed Papers
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