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  • 535311 - Poly(N-isopropylacrylamide)

535311 Sigma-Aldrich


Mn ~40,000

Synonym: NIPAM polymer, PNIPAM, Polyacrylamide, polyNIPAM



Related Categories Biomaterials, Hydrogels and Crosslinked Polymers, Hydrophilic Polymers, Materials Science, PNIPAM,
mol wt   Mn 20,000-60,000
  Mn ~40,000
mp   96 °C
SMILES string   CC(C)NC(=O)C=C
InChI   1S/C6H11NO/c1-3-5-7-6(8)4-2/h4H,2-3,5H2,1H3,(H,7,8)



PNIPAM-based Smart Surfaces for Cell Sheet Tissue Engineering

Thermosensitive polymer, can be used to form a hydrogel. Aqueous polymer solution undergoes a phase transition from a soluble to an insoluble state when the temperature is raised to ca. 32 °C.


10 g in glass bottle

Physical form

Thermosensitive polymer, hydrogel

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Protocols & Articles


Functional Polymers for Biomedical Applications

Wide range of functional polymers for biomedical applications have been synthesized and structurally characterized. Several classes of polymers including biodegradable polymers, hydrophilic & amphiph...
Gangadhar Panambur, Donghun Koo, Philip Dimitrov, Shahinur Rehman, Bryce Nelson, Viktor Balema
Keywords: Biomaterials, Building blocks, Polymerization reactions, Reversible addition-fragmentation chain transfer polymerizations

Micro- and Nanofabricated Biomaterials for the Study of Cells and Microtissues

Phin Peng Lee, Karen E. Samy, Miquella G. Chavez, Alec Cerchiari, Tejal A. Desai* Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 9415...
Keywords: Absorption, Adhesion, Amplification, Apoptosis, Biomaterials, Cancer, Cell culture, Cell proliferation, Diffusion, Immobilization, Indicators, Infrared spectroscopy, Ligands, Magnetic resonance imaging, Materials Science, Microscopy, Molecular biology, Nanotechnology, Semiconductor, Solvents

Poly(N-isopropylacrylamide)-based Smart Surfaces for Cell Sheet Tissue Engineering

Tissue engineering has become a key therapeutic tool in the treatment of damaged or diseased organs and tissues, such as blood vessels and urinary bladders.1 Nonetheless, major challenges still need ...
Masamichi NakayamaTeruo Okano and Françoise M. Winnik
Material Matters 2010, 5.3, 56.
Keywords: Adhesion, Biomaterials, Cell culture, Clinical, Dehydration reaction, Growth factors, Hydration reaction, Immobilization, Inflammation, Ligands, Magnetic resonance spectroscopy, Polymerization reactions, Radical polymerization, Rearrangements, Reversible addition-fragmentation chain transfer polymerizations, Solvents

Stimuli-Responsive Materials as Intelligent Drug Delivery Systems

Amit Singh and Mansoor M. Amiji* Department of Pharmaceutical Sciences, School of Pharmacy Northeastern University, Boston, MA 02115 USA *Email: m.amiji@neu.edu; Tel: 617-373-3137
Keywords: Absorption, Aerobic, Angiogenesis, Apoptosis, Atomic absorption spectroscopy, Cancer, Chromatin immunoprecipitation, Clinical, Deprotonations, Diseases, Electron spin resonance, Enzyme activity, Gastrointestinal, Glycolysis, Growth factors, Infrared spectroscopy, Ligands, Magnetic resonance imaging, Materials Science, Nanomaterials, Nanotubes, Pharmaceutical, Polymerization reactions, Sol-gel, transformation

Universal Platform for Surface Modification Employing Grafted Polymer Layers

Ultrathin (end-) grafted polymer layers are well known to affect dramatically the surface properties of substrates such as adhesion, lubrication, wettability, friction, and biocompatibility. The laye...
Bogdan Zdyrko, Viktor Klep, Igor Luzinov
Material Matters 2008, 3.2, 44.
Keywords: Adhesion, Materials Science, Microscopy, Nanotechnology, Polymer science, Polymerization reactions, Positron Emission Tomography, Radical polymerization, Ultraviolet-Visible spectroscopy

Peer-Reviewed Papers


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