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544639 Sigma-Aldrich

Methanesulfonylacetone

97%

Synonym: 1-(Methylsulfonyl)-2-propanone, NSC 35395

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Properties

Related Categories Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfones - Sulfur Compounds, Sulfur Compounds More...
InChI Key   NWEYGXQKFVGUFR-UHFFFAOYSA-N
assay   97%
form   powder or crystals
mp   48-52 °C (lit.)

Description

General description

Methanesulfonylacetone is a sulfonyl group-containing active methylene compound. It can react with Baylis–Hillman acetates in dimethylformamide/potassium carbonate system to form ortho-hydroxyacetophenone derivatives.

Application

Methanesulfonylacetone may be used in the preparation of 6-bromo-3-methanesulfonyl-2-methyl-quinolin-4-ol.

Reactant for:
• Stereoselective preparation of chiral cyclic ketones
• Preparation of poly-substituted pyridines
• Multicomponent cyclocondensation with aldehydes and aminoazoles
• Gold-catalyzed Friedlander cyclocondensation reaction
• Radical homoallylation reactions

Packaging

10 g in glass bottle

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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