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548081 Sigma-Aldrich

2,4-Difluorobenzenesulfonyl chloride

97%

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Properties

Related Categories Aryl Fluorinated Building Blocks, Building Blocks, C6, Chemical Synthesis, Fluorinated Building Blocks,
Quality Level   200
assay   97%
refractive index   n20/D 1.518 (lit.)
bp   236-237 °C (lit.)
density   1.581 g/mL at 25 °C (lit.)
SMILES string   Fc1ccc(c(F)c1)S(Cl)(=O)=O
InChI   1S/C6H3ClF2O2S/c7-12(10,11)6-2-1-4(8)3-5(6)9/h1-3H
InChI key   FJSAJUXIHJIAMD-UHFFFAOYSA-N

Description

General description

2,4-Difluorobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative.

Application

2,4-Difluorobenzenesulfonyl chloride may be used in the preparation of 2,4-difluoro-N,N-dimethylbenzenesulfonamide, a precursor for poly(aryl ether sulfonamide)s.
It may be used in the preparation of the following benzenesulfonamide quinoline derivatives with potent anti-HIV-1 (human immunodeficiency virus type 1) activity:
• 2,4-difluoro-N-methyl-N-(quinolin-8-yl)benzenesulfonamide
• N-ethyl-2,4-difluoro-N-(quinolin-8-yl)benzenesulfonamide
• 2,4-difluoro-N-(quinolin-8-yl)benzenesulfonamide

Packaging

25 g in poly bottle

5 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3265 8 / PGII
WGK Germany 
WGK 3
Flash Point(F) 
230.0 °F - closed cup
Flash Point(C) 
110 °C - closed cup

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Protocols & Articles
Peer-Reviewed Papers
15

References

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