• USA Home
  • 563110 - Diethyl azodicarboxylate solution

EMAIL THIS PAGE TO A FRIEND
563110 Aldrich

Diethyl azodicarboxylate solution

40 wt. % in toluene

Synonym: 1,2-Ethoxycarbonyl diazene solution, DEAD, Diethoxycarbonyldiazene solution, Diethyl azodiformate solution, NSC 3474, NSC 679015, Unifoam AZ-AE 200

  • CAS Number 1972-28-7

  • Linear Formula C2H5OCON=NCOOC2H5

  • Molecular Weight 174.15

  •  Beilstein Registry Number 908662

  •  MDL number MFCD00009103

  •  PubChem Substance ID 24880080

Purchase

Properties

Related Categories C-X Bond Formation (Non-Halogen), Chemical Synthesis, Mitsunobu, Synthetic Reagents
InChI Key   FAMRKDQNMBBFBR-BQYQJAHWSA-N
concentration   40 wt. % in toluene
refractive index   n20/D 1.4690
bp   116-117 °C
density   0.956 g/mL at 25 °C
storage temp.   2-8°C

Description

Application

A commonly used activating reagent in Mitsunobo reactions.

Reactant for preparation of:
• Immunostimulants α-Galactosylceramides
• Cellotriose and cellotetraose analogues as transition state mimics for mechanistic studies of cellulases
• Bisubstrate inhibitors with molecular recognition at the active site of catechol-O-methyltransferase
• Derivatives of F200 and S383 with cannabinoid CB1 receptor binding activities
• Aza-β-lactams via NHC-catalyzed [2 + 2] cycloaddition with ketenes

Reagent for:
• Annulation of N-protected imines
• α-thiocyanation of enolizable ketones with ammonium thiocyanate
• Diels-Alder reactions

General description

DOT Special Approval Submission is Under Review. Availability is Estimated as March 2012.

Packaging

100g unit contains ca. 40g DEAD solute

25g unit contains ca. 10g DEAD solute

25, 100 g in glass bottle

Warning

Toxic, Irritant, Flammable

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Precautionary statements 
RIDADR 
UN3379 - DOT UN3223 class 3 - PG 1 - Desensitized explosive, liquid, n.o.s. (Diethyl Azodicarboxylate 40% solution in toluene);Hi:ALL
WGK Germany 
3
Flash Point(F) 
105.8 °F
Flash Point(C) 
41 °C

Same Products - New Packaging

Screeing simplified
Protocols & Articles

Articles

Reagents for the Mitsunobu Reaction

One of the most powerful and widely used carboncarbon bond forming reactions in organic synthesis is the Mitsunobu reaction.1 The Mitsunobu reaction is also useful in the preparation of other moietie...
ChemFiles Volume 4 Article 2
Keywords: Mitsunobu Reaction, Organic synthesis

Related Content

Diethyl Azodicarboxylate in Chemical Synthesis

Diethyl azodicarboxylate (DEAD), a widely used reagent, is now available again from Sigma-Aldrich. Due to increased safety regulations, domestic shipment of DEAD as a dry reagent is prohibited. Sigma...
Keywords: Alkylations, Aminations, Asymmetric synthesis, Aza-Baylis-Hillman reaction, Baylis-Hillman Reaction, Catalysis, Compliance, Cycloadditions, Mitsunobu Reaction, Natural product synthesis, Silylations

Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

08168 Timestrip Plus 8 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?