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569747 Aldrich

Grubbs Catalyst 2nd Generation

Synonym: (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(phenylmethylene)(tricyclohexylphosphine)ruthenium, Benzylidene[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(tricyclohexylphosphine)ruthenium, Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene](benzylidene)(tricyclohexylphosphine)ruthenium(II), Grubbs Catalyst C848

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Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Packaging

100, 500 mg in glass bottle

2, 10 g in glass bottle

Application

Catalyst for ring-closing metathesis, cross metathesis and ROMP. Able to produce trisubstituted olefins via cross metathesis, and ring closes olefins with excellent functional group tolerance and selectivity.

Legal Information

Grubbs Catalyst is a trademark of Materia, Inc.

This product is subject to US patents 6,111,121 and 7,329,758 and associated foreign equivalents thereof. This product includes a limited one-time, non-exclusive, non-transferable license to use the Product for research purposes only. It is the sole responsibility of buyer to ensure that its use of the product does not infringe the rights of others. For questions, please contact us at aldrich@sial.com or Materia at info@materia-inc.com

Other Notes

Grubbs Catalyst Technology for Olefin Metathesis by Aldrich

569755 Hoveyda-Grubbs Catalyst 2nd Generation

For Bulk Inquiries,contact Materia

Price and Availability


LC-MS Grade Solvents and Reagents

KitAlysis - Increasing Catalysis Productivity
Safety & Documentation

Safety Information

Symbol 
GHS02  GHS02
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN1325 - class 4.1 - PG 2 - Flammable solids, organic, n.o.s., HI: all
WGK Germany 
3

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
What benefits does Product 569747, Grubbs Catalyst, 2nd Generation, have over other olefin metathesis catalysts?
Grubbs' Catalysts are extraordinarily versatile.  They tolerate other functional groups in the alkene and are compatible with a wide range of solvents.
What types of reactions is Product 569747, Grubbs Catalyst, 2nd Generation, used in?
It is often used in organic synthesis to achieve olefin cross-metathesis, ring-opening metathesis polymerization (ROMP), and ring-closing metathesis.
What is the difference between the First and Second Generation Grubbs Catalyst?
The Second Generation Catalyst has the same uses in organic synthesis as the First Generation Catalyst, but it has a higher activity.
How do I order larger quantities of Product 569747, Grubbs Catalyst, 2nd Generation?
Commercial quantities are available directly from Materia.  Their phone number is 626-584-8400, or their e-mail address is info@materia-inc.com.
Is it necessary to handle Product 569747, Grubbs Catalyst, 2nd Generation, under inert atmosphere?
The Grubbs Catalyst is air sensitive.  Therefore, we do recommend to handle and store under nitrogen atmosphere.
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
Show more questions
Protocols & Articles

Articles

Enyne Metathesis

Enyne metathesis has emerged as a powerful method for the synthesis of conjugated dienes.1 Botta and coworkers utilized a similar approach, where the olefin was replaced with an enol ether. Reaction ...
William Sommer
Aldrich ChemFiles 2009, 9.6, 7.
Keywords: Chemfiles, Enyne metathesis, Metathesis, Microwave synthesis

Grubbs Group - Professor Product Portal

From our library of Articles, Sigma-Aldrich presents Grubbs Group - Professor Product Portal
Keywords: Catalysis, Cross metathesis, Dihydroxylations, Ligands, Metathesis, Nuclear magnetic resonance spectroscopy, Olefin metathesis, Pharmaceutical, Spectroscopy, transformation

Ring Closing Metathesis Reaction Screening Kit Materials

The screening sets come pre-loaded with 1 µmol of catalyst in each vial according to the following design.
Keywords: High performance liquid chromatography, Metathesis, Ring-closing metathesis

Ring-Closing Metathesis | Aldrich ChemFiles 2009, 9.6, 4.

Ring-closing metathesis has become an essential tool for C-C bond formation as demonstrated by the profound impact on total synthesis in recent years.1 The first examples date back to 1980 and involv...
William Sommer
Aldrich ChemFiles 2009, 9.6, 4.
Keywords: C-C bond formation, Cyclizations, Metathesis, Ring-closing metathesis

Ruthenium-Based Metathesis Catalysts

Sigma-Aldrich is pleased to announce an agreement with Materia, Inc. to exclusively distribute research quantities of Grubbs catalysts and Hoveyda–Grubbs catalysts. For a recent review on cross-metat...
ChemFiles Volume 4 Article 2
Keywords: Aldrichimica Acta, Cross metathesis, Metathesis, Organic synthesis, Ring opening metathesis polymerisation, Ring-closing metathesis

Synthesis of Furans

Donohoe and co-workers have developed several synthetic approaches to the synthesis of furans which incorporate RCM as a key step.1 In 2007, the researchers synthesized a series of di- and tri-substi...
William Sommer
Aldrich ChemFiles 2009,9.6, 5.
Keywords: Anti-inflammatory agents, Chemfiles

Protocols

Olefin Metathesis Kit

Please consult the Safety Data Sheet for information regarding hazards and safe handling practices.
Keywords: Chromatography, Column chromatography, Gas chromatography, High performance liquid chromatography, PAGE, Thin layer chromatography

Olefin Metathesis in Water at Room Temperature using TPGS-750-M - Precautions, Procedures

TPGS-750-M, DL-α-Tocopherol methoxypolyethylene glycol succinate, is a designer surfactant composed of a lipophilic α-tocopherol moiety and a hydrophilic PEG-750-M chain, joined by an inexpensive suc...
Keywords: Catalysis, Chromatography, Coupling reactions, Cross couplings, Environmental, Flash chromatography, Metathesis, Olefin metathesis

Procedures for Transition-Metal-Catalyzed Cross-Coupling Reactions

TPGS-750-M, DL-α-Tocopherol methoxypolyethylene glycol succinate, is a designer surfactant composed of a lipophilic α-tocopherol moiety and a hydrophilic PEG-750-M chain, joined by an inexpensive suc...
Keywords: Aminations, Buchwald-Hartwig amination, Catalysis, Chromatography, Coupling reactions, Cross couplings, Environmental, Evaporation, Flash chromatography, Heck Reaction, Ligands, Metathesis, Olefin metathesis

Related Content

Metathesis in Chemical Synthesis

Olefin metathesis is now a well-entrenched synthetic technique, and is a powerful method for the clean construction of innumerable classes of chemical architectures. The broadly accepted belief that ...
Keywords: Building blocks, Cross metathesis, Enyne metathesis, Exothermic, Isomerizations, Ligands, Living polymerization, Metathesis, Olefin metathesis, Organic synthesis, Polymerization reactions, Ring opening metathesis polymerisation, Ring-closing metathesis

Peer-Reviewed Papers
15

References

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