• USA Home
  • 569755 - Hoveyda-Grubbs Catalyst® M72 (C627)

EMAIL THIS PAGE TO A FRIEND
569755 Sigma-Aldrich

Hoveyda-Grubbs Catalyst® M72 (C627)

Umicore, 97%

Synonym: (1,3-Bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(o-isopropoxyphenylmethylene)ruthenium, Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene](2-isopropoxyphenylmethylene)ruthenium(II), Grubbs Catalyst® C627, Hoveyda-Grubbs Catalyst® 2nd Generation

  • CAS Number 301224-40-8

  • Empirical Formula (Hill Notation) C31H38Cl2N2ORu

  • Molecular Weight 626.62

  •  MDL number MFCD03701614

  •  PubChem Substance ID 24880520

Purchase

Description

Application

Phosphine free version of Grubbs 2nd Generation Catalyst with comparable reactivity, but initiates more readily at lower temperatures. Efficient for metathesis of electron deficient substrates including fluorinated olefins. Demonstrated in multiple large-scale pharmaceutical applications.

Packaging

100, 500 mg in glass bottle

2, 10, 25 g in glass bottle

Other Notes

Grubbs Catalyst® Technology for Olefin Metathesis by Aldrich

Legal Information

Product of Umicore

Product License
This product, its manufacturing or use, is the subject of one or more issued or pending U.S. Patents (and foreign equivalents) owned or controlled by Umicore PMC. The purchase of this product from Umicore PMC through Sigma-Aldrich, its affiliates or their authorized distributors conveys to the buyer a limited, one-time, non-exclusive, non-transferable, non-assignable license. Buyer’s use of this product may infringe patents owned or controlled by third parties. It is the sole responsibility of buyer to ensure that its use of the product does not infringe the patent rights of third parties or exceed the scope of the license granted herein.
For any further information on product please refer to your local Umicore PMC contact at www.pmc.umicore.com.

Grubbs Catalyst is a registered trademark of Umicore

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

???PDP_SDS_LOT_NUMBER_ERROR_MSG???

Certificate of Origin

???PDP_SDS_LOT_NUMBER_ERROR_MSG???
Protocols & Articles

Articles

Exploiting Grubbs Catalysts with Novel Reactivity

The Howell group recently reported the first synthesis of tetrasubstituted olefins using cross metathesis during the course of investigating the synthesis of a-alkylidene-ß-lactams, which serve as bu...
William Sommer
Aldrich ChemFiles 2009, 9.6, 7.
Keywords: Antibiotics, Building blocks, Chemfiles, Cross metathesis, Metathesis

Grubbs Group - Professor Product Portal

From our library of Articles, Sigma-Aldrich presents Grubbs Group - Professor Product Portal
Keywords: Catalysis, Cross metathesis, Dihydroxylations, Ligands, Metathesis, Nuclear magnetic resonance spectroscopy, Olefin metathesis, Pharmaceutical, Spectroscopy, transformation

Ring Closing Metathesis Reaction Screening Kit Materials

The screening sets come pre-loaded with 1 µmol of catalyst in each vial according to the following design.
Keywords: High performance liquid chromatography, Metathesis, Ring-closing metathesis

Ring-Closing Metathesis | Aldrich ChemFiles 2009, 9.6, 4.

Ring-closing metathesis has become an essential tool for C-C bond formation as demonstrated by the profound impact on total synthesis in recent years.1 The first examples date back to 1980 and involv...
William Sommer
Aldrich ChemFiles 2009, 9.6, 4.
Keywords: C-C bond formation, Cyclizations, Metathesis, Ring-closing metathesis

Synthesis of Furans

Donohoe and co-workers have developed several synthetic approaches to the synthesis of furans which incorporate RCM as a key step.1 In 2007, the researchers synthesized a series of di- and tri-substi...
William Sommer
Aldrich ChemFiles 2009,9.6, 5.
Keywords: Anti-inflammatory agents, Chemfiles

Total Synthesis of Ingenol

In 2004, Wood and coworkers reported the synthesis of ingenol.1 This natural product has fascinated synthetic chemists for the past 20 years due to its promising biological activity and structure, wh...
William Sommer
Aldrich ChemFiles 2009,9.6, 4.
Keywords: Chemfiles, Cross metathesis, Metathesis, Polymerization reactions, Ring-closing metathesis

Related Content

Metathesis in Chemical Synthesis

Olefin metathesis is now a well-entrenched synthetic technique, and is a powerful method for the clean construction of innumerable classes of chemical architectures. The broadly accepted belief that ...
Keywords: Building blocks, Cross metathesis, Enyne metathesis, Exothermic, Isomerizations, Ligands, Living polymerization, Metathesis, Olefin metathesis, Organic synthesis, Polymerization reactions, Ring opening metathesis polymerisation, Ring-closing metathesis

Peer-Reviewed Papers
15

References

Related Products

related product

Product #

Description

Add to Cart

579726 Grubbs Catalyst® M1a (C823), Umicore, 97%
08168 Timestrip Plus 8 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?