• USA Home
  • 569755 - Hoveyda-Grubbs Catalyst® 2nd Generation

569755 Sigma-Aldrich

Hoveyda-Grubbs Catalyst® 2nd Generation


Synonym: (1,3-Bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(o-isopropoxyphenylmethylene)ruthenium, Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene](2-isopropoxyphenylmethylene)ruthenium(II), Grubbs Catalyst® C627

  • CAS Number 301224-40-8

  • Empirical Formula (Hill Notation) C31H38Cl2N2ORu

  • Molecular Weight 626.62

  •  MDL number MFCD03701614

  •  PubChem Substance ID 24880520




100, 500 mg in glass bottle

2, 10, 25 g in glass bottle


Phosphine free version of Grubbs 2nd Generation Catalyst with comparable reactivity, but initiates more readily at lower temperatures. Efficient for metathesis of electron deficient substrates including fluorinated olefins. Demonstrated in multiple large-scale pharmaceutical applications.

Legal Information

Grubbs Catalyst is a registered trademark of Umicore

This product is subject to US patent 6,921,735 and associated foreign equivalents thereof. This product includes a limited one-time, non-exclusive, non-transferable license to use the Product for research purposes only. It is the sole responsibility of buyer to ensure that its use of the product does not infringe the rights of others. For questions, please contact us at aldrich@sial.com

Other Notes

Grubbs Catalyst® Technology for Olefin Metathesis by Aldrich

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles


Exploiting Grubbs Catalysts with Novel Reactivity

The Howell group recently reported the first synthesis of tetrasubstituted olefins using cross metathesis during the course of investigating the synthesis of a-alkylidene-ß-lactams, which serve as bu...
William Sommer
Aldrich ChemFiles 2009, 9.6, 7.
Keywords: Antibiotics, Building blocks, Chemfiles, Cross metathesis, Metathesis

Grubbs Group - Professor Product Portal

From our library of Articles, Sigma-Aldrich presents Grubbs Group - Professor Product Portal
Keywords: Catalysis, Cross metathesis, Dihydroxylations, Ligands, Metathesis, Nuclear magnetic resonance spectroscopy, Olefin metathesis, Pharmaceutical, Spectroscopy, transformation

Ring Closing Metathesis Reaction Screening Kit Materials

The screening sets come pre-loaded with 1 µmol of catalyst in each vial according to the following design.
Keywords: High performance liquid chromatography, Metathesis, Ring-closing metathesis

Ring-Closing Metathesis | Aldrich ChemFiles 2009, 9.6, 4.

Ring-closing metathesis has become an essential tool for C-C bond formation as demonstrated by the profound impact on total synthesis in recent years.1 The first examples date back to 1980 and involv...
William Sommer
Aldrich ChemFiles 2009, 9.6, 4.
Keywords: C-C bond formation, Cyclizations, Metathesis, Ring-closing metathesis

Ruthenium-Based Metathesis Catalysts

We are pleased to announce an agreement with Materia, Inc. to exclusively distribute research quantities of Grubbs catalysts and Hoveyda–Grubbs catalysts. For a recent review on cross-metathesis of n...
ChemFiles Volume 4 Article 2
Keywords: Cross metathesis, Metathesis, Organic synthesis, Ring opening metathesis polymerisation, Ring-closing metathesis

Synthesis of Furans

Donohoe and co-workers have developed several synthetic approaches to the synthesis of furans which incorporate RCM as a key step.1 In 2007, the researchers synthesized a series of di- and tri-substi...
William Sommer
Aldrich ChemFiles 2009,9.6, 5.
Keywords: Anti-inflammatory agents, Chemfiles

Total Synthesis of Ingenol

In 2004, Wood and coworkers reported the synthesis of ingenol.1 This natural product has fascinated synthetic chemists for the past 20 years due to its promising biological activity and structure, wh...
William Sommer
Aldrich ChemFiles 2009,9.6, 4.
Keywords: Chemfiles, Cross metathesis, Metathesis, Polymerization reactions, Ring-closing metathesis

Related Content

Metathesis in Chemical Synthesis

Olefin metathesis is now a well-entrenched synthetic technique, and is a powerful method for the clean construction of innumerable classes of chemical architectures. The broadly accepted belief that ...
Keywords: Building blocks, Cross metathesis, Enyne metathesis, Exothermic, Isomerizations, Ligands, Living polymerization, Metathesis, Olefin metathesis, Organic synthesis, Polymerization reactions, Ring opening metathesis polymerisation, Ring-closing metathesis

Peer-Reviewed Papers


Related Products

related product

Product #


Add to Cart

579726 Grubbs Catalyst® 1st Generation, 97%
08168 Timestrip Plus 8 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?