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577944 Sigma-Aldrich

Hoveyda-Grubbs Catalyst® 1st Generation

Synonym: Dichloro(2-isopropoxyphenylmethylene) (tricyclohexylphosphine)ruthenium(II), Dichloro(o-isopropoxyphenylmethylene)(tricyclohexylphosphine)ruthenium(II), Grubbs Catalyst C601




100, 500 mg in glass bottle

2 g in glass bottle

Legal Information

This product is subject to one or more US patents and associated foreign equivalents thereof including, without limitation US 6,620,955; US 7,026,495; US 7,268,242; US 8,754,249. This product includes a limited one-time, non-exclusive, non-transferable license to use the Product for research purposes only. It is the sole responsibility of buyer to ensure that its use of the product does not infringe the rights of others. For questions, please contact us at aldrich@sial.com

Grubbs Catalyst is a registered trademark of Umicore


Proven to be useful in Ring-Closing Metathesis (RCM) to form macrocycles. Also employed in a pivotal, macrocyclic ring-closing metathesis in the multi-step synthesis of an HCV protease inhibitor.

Other Notes

Grubbs Catalyst® Technology for Olefin Metathesis by Aldrich

Safety & Documentation

Safety Information

GHS02  GHS02
Signal word 
Hazard statements 
Precautionary statements 
UN1325 - class 4.1 - PG 2 - Flammable solids, organic, n.o.s., HI: all
WGK Germany 
Protocols & Articles


Grubbs Group - Professor Product Portal

From our library of Articles, Sigma-Aldrich presents Grubbs Group - Professor Product Portal
Keywords: Catalysis, Cross metathesis, Dihydroxylations, Ligands, Metathesis, Nuclear magnetic resonance spectroscopy, Olefin metathesis, Pharmaceutical, Spectroscopy, transformation

Ring-Closing Metathesis | Aldrich ChemFiles 2009, 9.6, 4.

Ring-closing metathesis has become an essential tool for C-C bond formation as demonstrated by the profound impact on total synthesis in recent years.1 The first examples date back to 1980 and involv...
William Sommer
Aldrich ChemFiles 2009, 9.6, 4.
Keywords: C-C bond formation, Cyclizations, Metathesis, Ring-closing metathesis

Ruthenium-Based Metathesis Catalysts

We are pleased to announce an agreement with Materia, Inc. to exclusively distribute research quantities of Grubbs catalysts and Hoveyda–Grubbs catalysts. For a recent review on cross-metathesis of n...
ChemFiles Volume 4 Article 2
Keywords: Cross metathesis, Metathesis, Organic synthesis, Ring opening metathesis polymerisation, Ring-closing metathesis

Related Content

Metathesis in Chemical Synthesis

Olefin metathesis is now a well-entrenched synthetic technique, and is a powerful method for the clean construction of innumerable classes of chemical architectures. The broadly accepted belief that ...
Keywords: Building blocks, Cross metathesis, Enyne metathesis, Exothermic, Isomerizations, Ligands, Living polymerization, Metathesis, Olefin metathesis, Organic synthesis, Polymerization reactions, Ring opening metathesis polymerisation, Ring-closing metathesis

Peer-Reviewed Papers


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