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579726 Sigma-Aldrich

Grubbs Catalyst® 1st Generation


Synonym: Benzylidene-bis(tricyclohexylphosphine)dichlororuthenium, Bis(tricyclohexylphosphine)benzylidine ruthenium(IV) dichloride, Dichloro(benzylidene)bis(tricyclohexylphosphine)ruthenium(II), Grubbs Catalyst® C823




1, 5, 50 g in glass bottle


First metathesis catalyst to be widely used in organic synthesis. Useful in Ring-Opening Metathesis Polymerization (ROMP) of strained cyclic olefins, in Olefin cross metathesis (CM) and Ring closing metathesis (RCM) of terminal olefins under a variety of reactions conditions. Used to form stapled peptides.

Legal Information

Grubbs Catalyst is a registered trademark of Umicore

This product is subject to US patent 6,111,121 and associated foreign equivalents thereof. This product includes a limited one-time, non-exclusive, non-transferable license to use the Product for research purposes only. It is the sole responsibility of buyer to ensure that its use of the product does not infringe the rights of others. For questions, please contact us at aldrich@sial.com

Other Notes

Grubbs Catalyst® Technology for Olefin Metathesis by Aldrich

Safety & Documentation

Safety Information

Signal word 
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
UN1325 - class 4.1 - PG 2 - Flammable solids, organic, n.o.s., HI: all
WGK Germany 
Protocols & Articles


Grubbs Group - Professor Product Portal

From our library of Articles, Sigma-Aldrich presents Grubbs Group - Professor Product Portal
Keywords: Catalysis, Cross metathesis, Dihydroxylations, Ligands, Metathesis, Nuclear magnetic resonance spectroscopy, Olefin metathesis, Pharmaceutical, Spectroscopy, transformation

Ring Closing Metathesis Reaction Screening Kit Materials

The screening sets come pre-loaded with 1 µmol of catalyst in each vial according to the following design.
Keywords: High performance liquid chromatography, Metathesis, Ring-closing metathesis

Ring-Closing Metathesis | Aldrich ChemFiles 2009, 9.6, 4.

Ring-closing metathesis has become an essential tool for C-C bond formation as demonstrated by the profound impact on total synthesis in recent years.1 The first examples date back to 1980 and involv...
William Sommer
Aldrich ChemFiles 2009, 9.6, 4.
Keywords: C-C bond formation, Cyclizations, Metathesis, Ring-closing metathesis

Ruthenium-Based Metathesis Catalysts

We are pleased to announce an agreement with Materia, Inc. to exclusively distribute research quantities of Grubbs catalysts and Hoveyda–Grubbs catalysts. For a recent review on cross-metathesis of n...
ChemFiles Volume 4 Article 2
Keywords: Cross metathesis, Metathesis, Organic synthesis, Ring opening metathesis polymerisation, Ring-closing metathesis

Synthesis of Glabrescol

In 2000, Corey and coworkers utilized cross metathesis to synthesize a series of stereoisomers of glabrescol.1 Glabrescol is the biosynthetic precursor to steroids and triterpenoids. Upon preparation...
William Sommer
Aldrich ChemFiles 2009, 9.6, 7.
Keywords: Chemfiles, Cross metathesis, Metathesis

Total Synthesis of Ingenol

In 2004, Wood and coworkers reported the synthesis of ingenol.1 This natural product has fascinated synthetic chemists for the past 20 years due to its promising biological activity and structure, wh...
William Sommer
Aldrich ChemFiles 2009,9.6, 4.
Keywords: Chemfiles, Cross metathesis, Metathesis, Polymerization reactions, Ring-closing metathesis

Related Content

Metathesis in Chemical Synthesis

Olefin metathesis is now a well-entrenched synthetic technique, and is a powerful method for the clean construction of innumerable classes of chemical architectures. The broadly accepted belief that ...
Keywords: Building blocks, Cross metathesis, Enyne metathesis, Exothermic, Isomerizations, Ligands, Living polymerization, Metathesis, Olefin metathesis, Organic synthesis, Polymerization reactions, Ring opening metathesis polymerisation, Ring-closing metathesis

Peer-Reviewed Papers


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