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58790 Sigma-Aldrich

(+)-Potassium Ds-threo-isocitrate monobasic

≥98.0% (NT)

Synonym: (1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid monopotassium salt, Ds-(+)-threo-Isocitric acid monopotassium salt

  • CAS Number 20226-99-7

  • Empirical Formula (Hill Notation) C6H7KO7

  • Molecular Weight 230.21

  •  Beilstein/REAXYS Number 3767339

  •  PubChem Substance ID 57651660

  •  NACRES NA.22

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Properties

Related Categories Asymmetric Synthesis, Cancer Metabolism, Cancer Research, Carboxylic Acid Salts, Cell Biology,
InChI Key   IVLPTBJBFVJENN-LEJBHHMKSA-M
assay   ≥98.0% (NT)
optical activity   [α]20/D +20.5±1°, c = 2% in H2O
mp   ~185 °C (dec.)

Description

Application

(+)-Potassium Ds-threo-isocitrate monobasic may be used in the assessment of isocitrate dehydrogenase 2 (Idh2) activity by Kornberg method.

Packaging

1 g in glass bottle

250 mg in glass bottle

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Substrate for the characterization of isocitrate dehydrogenase

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

LCMS Separation and Identification of 2-Hydroxyglutarates

Sigma-Aldrich has recently developed an application for the separation and identification of S-2-hydroxyglutaric acids and R-2-hydroxyglutaric acids by chiral LC-MS, using a CHIROBIOTIC® R Column (co...
Keywords: AGE, Cancer, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Reductions, Separation, Tools

The Krebs cycle — harnessing chemical energy for cellular respiration

The tricarboxylic acid (TCA) cycle, also known as the Krebs or citric acid cycle, is the main source of energy for cells and an important part of aerobic respiration. The cycle harnesses the availabl...
Keywords: Addition reactions, Aerobic, Biochemistry, Catalysis, Citric Acid Cycle, Decarboxylations, Dehydration reaction, Diseases, Enzyme activity, Glycolysis, Hydration reaction, Lipid Metabolism, Mass spectrometry, Metabolism, Metabolites, Metabolomics, Oxidations, Phosphorylations, Respiration

Peer-Reviewed Papers
15

References

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