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  • 589284 - 1-[(Trimethylsilyl)methyl]benzotriazole

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589284 Sigma-Aldrich

1-[(Trimethylsilyl)methyl]benzotriazole

99%

  • CAS Number 122296-00-8

  • Empirical Formula (Hill Notation) C10H15N3Si

  • Molecular Weight 205.33

  •  MDL number MFCD00956443

  •  PubChem Substance ID 24881071

  •  NACRES NA.22

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Properties

Related Categories C-C Bond Formation, Chemical Synthesis, Other Synthetic Reagents for C-C Bond Formation, Synthetic Reagents
Quality Level   100
assay   99%
reaction suitability   reaction type: C-C Bond Formation
mp   56-60 °C (lit.)
SMILES string   C[Si](C)(C)Cn1nnc2ccccc12
InChI   1S/C10H15N3Si/c1-14(2,3)8-13-10-7-5-4-6-9(10)11-12-13/h4-7H,8H2,1-3H3
InChI key   VRGRHLJMRVGQCS-UHFFFAOYSA-N

Description

Application

New Benzotriazole Reagents

Reactant for:
• Alkylation reactions
• Preparation of inhibitor of p53-MDM2 complex formation

• Used as a one-carbon synthon for one-carbon homologation of carboxylic acids

Packaging

5 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Benzotriazole Reagents

Benzotriazole has been commonly employed as a leaving group and has been used extensively as a novel synthetic auxiliary.  Much of its attractiveness lies in its ability to be introduced readily and ...

Related Content

Benzotriazole Reagents in Chemical Synthesis

Benzotriazole has been commonly employed as a leaving group and has been used extensively as a novel synthetic auxiliary.  Much of its attractiveness lies in its ability to be introduced readily and ...
Keywords: Aldrichimica Acta, Methods

Indoles, Purines, and Their Isosteres

Substituted indoles and purines have frequently been referred to as “privileged structures” since they are capable of binding to multiple receptors with high affinity, and thus have applications acro...
Keywords: Building blocks, Medicinal chemistry

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