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592277 Sigma-Aldrich

2-Chlorobenzimidazole

98%

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Properties

Related Categories Benzimidazoles, Building Blocks, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks More...
InChI Key   AYPSHJCKSDNETA-UHFFFAOYSA-N
assay   98%
mp   207-211 °C (lit.)

Description

General description

2-Chlorobenzimidazole can be synthesized by reacting benzimidazole-2-one with phosphoryl chloride in the presence of phenol.

Application

2-Chlorobenzimidazole can be used to synthesize the following:
• 1-methyl-2-chlorobenzimidazole via reaction with dimethyl sulfate
• 1-ethyl-2-chlorobenzimidazole via reaction with diethyl sulfate
• 1-benzyl-2-chlorobenzimidazole via reaction with benzyl chloride
• 2-chloro-4,5,6,7-tetrabromobenzimidazole via bromination with bromine
It may be used as a building block to synthesize 4-amino-6-benzimidazole-pyrimidines.

Packaging

5, 25 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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