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  • 653233 - 2,4-Dichloro-5-fluoropyrimidine

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653233 Sigma-Aldrich

2,4-Dichloro-5-fluoropyrimidine

97%

  • CAS Number 2927-71-1

  • Empirical Formula (Hill Notation) C4HCl2FN2

  • Molecular Weight 166.97

  •  MDL number MFCD00233551

  •  PubChem Substance ID 24883938

  •  NACRES NA.22

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Properties

Related Categories Building Blocks, C4 to C5, Chemical Synthesis, Fluorinated Building Blocks, Halogenated Heterocycles,
assay   97%
mp   37-41 °C (lit.)
storage temp.   room temp
SMILES string   Fc1cnc(Cl)nc1Cl
InChI   1S/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H
InChI key   WHPFEQUEHBULBW-UHFFFAOYSA-N

Description

Application

2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize:
•  5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors.
•  A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors.
•  2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors.
•  5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA.
•  2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst.
•  5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.

Packaging

1 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 3261 8 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
222.8 °F - closed cup
Flash Point(C) 
106 °C - closed cup

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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