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  • 665266 - (+)-1,2-Bis[(2S,5S)-2,5-dimethylphospholano]benzene

665266 Sigma-Aldrich


kanata purity

Synonym: (2S,2′S,5S,5′S)-2,2′,5,5′-Tetramethyl-1,1′-(o-phenylene)diphospholane, (S,S)-Me-DUPHOS, (S,S)-Methyl-DUPHOS

  • CAS Number 136735-95-0

  • Empirical Formula (Hill Notation) C18H28P2

  • Molecular Weight 306.36

  •  Beilstein/REAXYS Number 4810602

  •  MDL number MFCD00142322

  •  PubChem Substance ID 24884725

  •  NACRES NA.22



Related Categories Asymmetric Synthesis, Chemical Synthesis, Chiral Catalysts, Ligands, and Reagents, DuPhos/BPE, Privileged Ligands and Complexes More...
Quality Level   100
mp   67-76 °C
SMILES string   C[C@H]1CC[C@H](C)P1c2ccccc2P3[C@@H](C)CC[C@@H]3C
InChI   1S/C18H28P2/c1-13-9-10-14(2)19(13)17-7-5-6-8-18(17)20-15(3)11-12-16(20)4/h5-8,13-16H,9-12H2,1-4H3/t13-,14-,15-,16-/m0/s1



DuPhos and BPE Ligands: Highly Efficient Privileged Ligands


100 mg in clear glass bottle

500 mg in amber glass bottle

Legal Information

Sold in collaboration with Kanata Chemical Technologies, Inc. for research purposes only. These compounds were made and sold under license from E.I. du Pont de Nemours and Company, which license does not include the right to use the compounds in producing products for sale in the pharmaceutical field.

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles


DuPhos and BPE Phospholane Ligands and Complexes

In the early 1990s, Burk and coworkers developed new electron-rich C2 symmetric bis(phospholane) ligands. The modular nature of these ligands allowed for variation of both phosphane substituent and b...
William Sommer and Daniel Weibel
ChemFiles 2008, 8.2, 34.
Keywords: Aminations, Asymmetric catalysis, Asymmetric synthesis, Building blocks, Catalysis, Crotylborations, Hydrogenations, Ligands, Reductions, Reductive aminations

Hydrogenation Catalysts and Ligands

Sigma-Aldrich is proud to offer new catalysts for hydrogenation through our collaboration with Kanata Chemical Technologies.1 The Ir and Ru complexes highlighted herein are especially active in the h...
Chemfiles Volume 6 Article 1
Keywords: Asymmetric synthesis, Building blocks, Catalysis, Company, Hydrogenations, Infrared spectroscopy, Ligands, Pharmaceutical, Reductions

Related Content

DuPhos and BPE Ligands: Highly Efficient Privileged Ligands

Introduction Asymmetric hydrogenation reactions represent the ideal process for the commercial manufacture of single-enantiomer compounds, because of the ease by which these robust procedures can be ...
Keywords: Addition reactions, Alkylations, Amidations, Aminations, Asymmetric synthesis, Building blocks, Catalysis, Cycloadditions, Electronics, Hydrogenations, Ligands, Pharmaceutical, Purification, Reductions, Reductive aminations, transformation

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