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667005 Sigma-Aldrich

(R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane

97%

Synonym: (R)-(+)-2-(Trifluoromethyl)oxirane

  • CAS Number 143142-90-9

  • Empirical Formula (Hill Notation) C3H3F3O

  • Molecular Weight 112.05

  •  MDL number MFCD08276876

  •  PubChem Substance ID 24884878

  •  NACRES NA.22

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Properties

Related Categories Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Epoxides, Organic Building Blocks More...
Quality Level   100
assay   97%
refractive index   n20/D <1.300
bp   25-32 °C
density   1.294 g/mL at 25 °C
storage temp.   2-8°C
SMILES string   FC(F)(F)[C@H]1CO1
InChI   1S/C3H3F3O/c4-3(5,6)2-1-7-2/h2H,1H2/t2-/m1/s1
InChI key   AQZRARFZZMGLHL-UWTATZPHSA-N

Description

Application

(R)-(+)-3,3,3-Trifluoro-1,2-epoxypropane can be used as a substrate to synthesize:
•  Substituted trifluoro amino propanols, which are found to be potent inhibitors of cholesteryl ester transfer protein.
•  (2R) Trifluoro-(methoxybenzyloxy)-propanol (chiral glycol) by reacting with 4-methoxybenzyl alcohol in the presence of NaH. Chiral glycol intermediate is further utilized for the preparation of trifluoromethyl glycol carbamates as potential monoacylglycerol lipase (MAGL) inhibitors.

Packaging

1 g in glass bottle

250 mg in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS02  GHS02
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 1993A 3 / PGI
WGK Germany 
WGK 3
Flash Point(F) 
-14.8 °F
Flash Point(C) 
-26 °C
Protocols & Articles
Peer-Reviewed Papers
15

References

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