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  • 676632 - 5-(Di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole

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676632 Sigma-Aldrich

5-(Di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole

97%

Synonym: BippyPhos

  • CAS Number 894086-00-1

  • Empirical Formula (Hill Notation) C32H35N4P

  • Molecular Weight 506.62

  •  MDL number MFCD09038440

  •  PubChem Substance ID 24884860

  •  NACRES NA.22

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Properties

Related Categories Catalysis and Inorganic Chemistry, Chemical Synthesis, Cross-Coupling, Non-Proprietary Phosphine Ligands, Phosphine Compounds,
assay   97%
mp   169-173 °C
functional group   phosphine
reaction suitability   reaction type: Cross Couplings
  reagent type: ligand
reaction type: Amidations
  reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
  reagent type: ligand
reaction type: Coupling Reactions
SMILES string   CC(C)(C)P(c1ccnn1-c2c(nn(-c3ccccc3)c2-c4ccccc4)-c5ccccc5)C(C)(C)C
InChI   1S/C32H35N4P/c1-31(2,3)37(32(4,5)6)27-22-23-33-36(27)30-28(24-16-10-7-11-17-24)34-35(26-20-14-9-15-21-26)29(30)25-18-12-8-13-19-25/h7-23H,1-6H3
InChI key   PTXJGGGNGMPMBG-UHFFFAOYSA-N

Description

Application

Non-proprietary ligand for palladium-catalyzed amination of aryl halides including aryl chlorides. Works best when the palladium source is Pd2(dba)3 (328774).

Packaging

1 g in glass bottle

250 mg in glass bottle

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Aldrich ChemFiles 2007, 7.10, 6.| Non-Proprietary Phosphine Ligands

In the pharmaceutical industry, Pd-catalyzed processes have frequently been relied on for carrying out key bond formations. While there are many ligands that efficiently mediate C–C and C–N bond form...
William Sommer
Aldrich ChemFiles 2007, 7.10, 6.
Keywords: Aminations, Catalysis, Coupling reactions, Cross couplings, Eliminations, Ligands, Pharmaceutical

Peer-Reviewed Papers
15

References

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