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678740 Sigma-Aldrich

Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)

Synonym: (A-taPhos)2PdCl2, Pd(amphos)Cl2

  • CAS Number 887919-35-9

  • Empirical Formula (Hill Notation) C32H56Cl2N2P2Pd

  • Molecular Weight 708.07

  •  MDL number MFCD09265123

  •  PubChem Substance ID 24885453

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Description

Application

Application Guide for Palladium Catalyzed Cross-Coupling Reactions

Higly active, air-stable catalyst for Suzuki-Miyaura cross-coupling with aryl halides including 5- and 6-membered heteroaryl chlorides.

Packaging

1, 5, 50 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles

Articles

Advantages of A-Phos Palladium Complexes for Efficient Suzuki Coupling

The Suzuki-Miyaura cross-coupling reaction of heteroaryl halides is of particular interest to the pharmaceutical industry since many biologically active compounds are accessed through this methodolog...
Keywords: Catalysis, Coupling reactions, Cross couplings, Pharmaceutical, Solvents, Suzuki coupling

Aldrich ChemFiles 2007, 7.10, 6.| Non-Proprietary Phosphine Ligands

In the pharmaceutical industry, Pd-catalyzed processes have frequently been relied on for carrying out key bond formations. While there are many ligands that efficiently mediate C–C and C–N bond form...
William Sommer
Aldrich ChemFiles 2007, 7.10, 6.
Keywords: Aminations, Catalysis, Coupling reactions, Cross couplings, Eliminations, Ligands, Pharmaceutical

Non-Proprietary Catalysts for Cross-Coupling Reaction

The cross-coupling reaction of heteroaryl halides is of particular interest to the pharmaceutical industry since many biologically active compounds are accessed through use of the Suzuki-Miyaura reac...
Josephine Nakhla
Chemfiles Volume 10 Article 3
Keywords: Catalysis, Chemfiles, Coupling reactions, Cross couplings, Pharmaceutical

Suzuki-Miyaura Cross-Coupling of Potassium Dioxolanylethyltrifluoroborate and Aryl/Heteroaryl Chlorides

A robust and general catalyst system�facilitates the alkoxylation of activated heteroaryl halides with primary, secondary, and select tertiary alcohols without the need for an excess of either coupli...
Keywords: High performance liquid chromatography, Liquid chromatography mass spectrometry, Purification

Protocols

Negishi Kit

Please consult the Safety Data Sheet for information regarding hazards and safe handling practices.
Keywords: Chromatography, Column chromatography, Gas chromatography, High performance liquid chromatography, Thin layer chromatography

Negishi Reaction in Water at Room Temperature using TPGS-750-M - Procedures, Precautions, Materials

TPGS-750-M, DL-α-Tocopherol methoxypolyethylene glycol succinate, is a designer surfactant composed of a lipophilic α-tocopherol moiety and a hydrophilic PEG-750-M chain, joined by an inexpensive suc...
Keywords: Catalysis, Chromatography, Coupling reactions, Cross couplings, Environmental, Flash chromatography

Procedures for Transition-Metal-Catalyzed Cross-Coupling Reactions

TPGS-750-M, DL-α-Tocopherol methoxypolyethylene glycol succinate, is a designer surfactant composed of a lipophilic α-tocopherol moiety and a hydrophilic PEG-750-M chain, joined by an inexpensive suc...
Keywords: Aminations, Buchwald-Hartwig amination, Catalysis, Chromatography, Coupling reactions, Cross couplings, Environmental, Evaporation, Flash chromatography, Heck Reaction, Ligands, Metathesis, Olefin metathesis

Related Content

A-Phos Palladium Complexes for Efficient Suzuki Coupling

Introduction The Suzuki-Miyaura cross-coupling reaction of heteroaryl halides is of particular interest to the pharmaceutical industry since many biologically active compounds are accessed through th...
Keywords: Applications, Catalysis, Coupling reactions, Cross couplings, Pharmaceutical, Solvents, Suzuki coupling

Application Guide for Palladium Catalyzed Cross-Coupling Reactions

Palladium catalyzed cross-coupling reactions have revolutionized the way in which molecules are constructed. From the fields of organic synthesis and medicinal chemistry, to materials science and pol...
Keywords: Catalysis, Coupling reactions, Cross couplings, Materials Science, Medicinal chemistry, Organic synthesis, Polymer science, transformation

Peer-Reviewed Papers
15

References

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