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679097 Sigma-Aldrich

(R)-(−)-2-Methylpyrrolidine

  • CAS Number 41720-98-3

  • Empirical Formula (Hill Notation) C5H11N

  • Molecular Weight 85.15

  •  MDL number MFCD07783026

  •  PubChem Substance ID 24885467

  •  NACRES NA.22

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Properties

Related Categories Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Heterocyclic Building Blocks, Pyrrolidines More...
InChI Key   RGHPCLZJAFCTIK-RXMQYKEDSA-N
refractive index   n20/D 1.4353
density   0.842 g/mL at 25 °C (lit.)
storage temp.   2-8°C

Description

Application

(R)-(-)-2-Methylpyrrolidine, an optically active amine, is a key building block for a series of histamine H3 receptor antagonists.

Building block used in a multikilogram synthesis of a chiral naphthalenoid histamine receptor antagonist.

Packaging

1 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2924 8(3) / PGII
WGK Germany 
3
Flash Point(F) 
44.6 °F
Flash Point(C) 
7 °C

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Pyrrolidines

The (R)-2-methylpyrrolidinyl fragment has been a common structural motif present in several recently reported inhibitors and antagonists. One group synthesized a series of HIV-1 reverse transcriptase...
Aldrich ChemFiles 2007, 7.8, 9.
Keywords: Building blocks

Peer-Reviewed Papers
15

References

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