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  • 698385 - 1,2-Bis[(2S,5S)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate

698385 Sigma-Aldrich

1,2-Bis[(2S,5S)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate

Synonym: (S,S)-Et-DUPHOS-Rh

  • CAS Number 213343-64-7

  • Empirical Formula (Hill Notation) C30H48BF4P2Rh

  • Molecular Weight 660.36

  •  PubChem Substance ID 329761249




50, 250 mg in amber glass bottle

Legal Information

Sold in collaboration with Kanata Chemical Technologies Inc. for research purposes only. These compounds were made and sold under license from E.I. du Pont de Nemours and Company, which license does not include the right to use the compounds in producing products for sale in the pharmaceutical field.


DuPhos and BPE Ligands: Highly Efficient Privileged Ligands

Catalyst for:
• Preparation of a key unit B precursor of cryptophycins via Horner-Wadsworth-Emmons reaction and asymmetric hydrogenation
• Preparation of constrained phenylalanine analogs via Heck reaction followed by asymmetric hydrogenation and cyclization steps
• Enantioselective preparation of N-benzyloxy-β-amino acid Me esters by hydrogenation of α-(benzyloxyaminomethyl)acrylate stereoisomers
• Preparation of fluoro amino acids as synthons for potent macrocyclic HCV NS3 protease inhibitors
• Stereoselective preparation of triply isotope-labeled Ser, Cys, and Ala
• Preparation of β-amino acids from asymmetric hydrogenation of α-(aminomethyl)acrylates
• Asymmetric hydrogenation of a-primary and secondary amino ketones and asymmetric synthesis of (-)-arbutamine and (-)-denopamine

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles


DuPhos and BPE Phospholane Ligands and Complexes

In the early 1990s, Burk and coworkers developed new electron-rich C2 symmetric bis(phospholane) ligands. The modular nature of these ligands allowed for variation of both phosphane substituent and b...
William Sommer and Daniel Weibel
Aldrich ChemFiles 2008, 8.2, 34.
Keywords: Aminations, Applications, Asymmetric catalysis, Asymmetric synthesis, Building blocks, Catalysis, Chemfiles, Crotylborations, Hydrogenations, Ligands, Reductions, Reductive aminations

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