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704954 Sigma-Aldrich

XPhos Pd G1

Synonym: (2-Dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl)]palladium(II) chloride, (XPhos) palladium(II) phenethylamine chloride, Chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl)]palladium(II), XPhos Palladacycle, XPhos precatalyst

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Description

General description

Material may contain up to 5% pentane

Application

Application Guide for Palladium Catalyzed Cross-Coupling Reactions

Catalyst used for:
• Amination / cyclization reactions
• C-N bond-forming reactions via packed-bed microreactors
• Boration of aryl chlorides
• Arylation of oxazole
• Cross-coupling reactions

Packaging

1, 25 g in glass bottle

250 mg in glass bottle

Legal Information

Usage subject to US Patents 6307087 and 6395916.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles

Articles

Advantages of Air-Stable Precatalysts for Amination

C–N bond forming cross-couplings typically require a palladium (Pd) source along with the associated ligands. Most Pd(0) sources are not air-stable, while the commonly employed air-stable Pd(0) sourc...
Dr. Josephine Nakhla
Chemfiles Volume 10 Article 1
Keywords: Arylations, Cross couplings, Ligands, Reductions

Selective Monoarylation of Acetate Esters and Aryl Methyl Ketones Using Aryl Chlorides

A series of palladacyclic precatalysts that incorporate electron-rich di-tert-butylphosphino biaryl ligands is reported. These precatalysts are easily prepared, and their use provides a general means...
Keywords: Amidations, Catalysis, Chromatography, Coupling reactions, Cross couplings, Flash chromatography, Ligands, Thin layer chromatography

Stephen Buchwald Group – Professor Product Portal

From our library of Articles, Sigma-Aldrich presents Stephen Buchwald Group – Professor Product Portal
Keywords: Aminations, Asymmetric catalysis, Asymmetric synthesis, Catalysis, Coupling reactions, Cross couplings, Fluorinations, Ligands, Solvents, transformation

Technical Article | Air-Stable Precatalysts for Amination

C–N bond forming cross-couplings typically require a palladium source along with the associated ligands. Most Pd(0) sources are not air-stable, while the commonly employed air-stable Pd(0) source, Pd...
Josephine Nakhla
Chemfiles Volume 10 Article 3
Keywords: Arylations, Chemfiles, Cross couplings, Ligands, Reductions

Related Content

Application Guide for Palladium Catalyzed Cross-Coupling Reactions

Palladium catalyzed cross-coupling reactions have revolutionized the way in which molecules are constructed. From the fields of organic synthesis and medicinal chemistry, to materials science and pol...
Keywords: Catalysis, Coupling reactions, Cross couplings, Materials Science, Medicinal chemistry, Organic synthesis, Polymer science, transformation

Buchwald Precatalysts and Ligand Guide

Dialkylbiaryl phospine ligands, and the precatalysts derived from them, are commonly referred to as Buchwald Precatalysts and Ligands. These reagents have developed into a highly valuable class of co...
Keywords: Catalysis, Ligands

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