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712191 Aldrich

COMU® Green Alternative

97%

Synonym: (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino-carbenium hexafluorophosphate

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Properties

Related Categories 12 Principles Aligned Products, Chemical Biology, Chemical Synthesis, Coupling, Greener Alternative Products,
InChI Key   GPDHNZNLPKYHCN-DZOOLQPHSA-N
assay   ≥96.5% (TLC)
  96.5-103.5% (T)
  97%
greener alternative product characteristics   Catalysis
Learn more about the Principles of Green Chemistry.
storage temp.   2-8°C

Description

Packaging

5, 25, 100 g in poly bottle

Application

Morpholine-Based Immonium and Halogenoamidinium Salts as Coupling Reagents in Peptide Synthesis

COMU – Safer and More Efficient Peptide Coupling Reagent

Advantages
• Equal or even superior performance to HATU
• Non-explosive (does not contain benzotriazole moiety)
• Suitable for solution phase & solid phase peptide synthesis
• Utmost retention of configuration – low to non-existent racemization
• High solubility and stability in typical solvents
• Visual or colorimetric reaction monitoring possible
• Easy removal of water-soluble by-products

General description

Sigma Life Science is committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for energy efficiency. Find details here.

Legal Information

COMU is a registered trademark of Luxembourg Bio Technologies Ltd.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Same Products - New Packaging

Screeing simplified
Protocols & Articles

Articles

COMU—Safer and More Efficient Peptide Coupling Reagent

Proteins and peptides are ubiquitous in all living systems. The chemical synthesis of peptidic structures for scientific research or drug discovery relies heavily on efficient coupling reagents. This...
Dr. Matthias Junkers
Aldrich Chemfiles, 2010 Volume 10 Article 1
Keywords: Calorimetry, Coupling reactions, Drug discovery, Epimerizations, Microwave synthesis, Peptide synthesis, Racemizations, Reductions, Solid phase peptide synthesis, Solvents

Protocols

Amide Coupling Kit

Please consult the Safety Data Sheet for information regarding hazards and safe handling practices.
Keywords: Chromatography, Column chromatography, PAGE, Peptide synthesis, Purification, Solvents, Thin layer chromatography

Related Content

COMU – Safer and More Efficient Peptide Coupling Reagent

Peptide synthesis relies heavily on efficient and reliable coupling reagents. A low tendency for racemization is a key requirement. This is especially true for solid phase peptide synthesis—quantitat...
Keywords: Building blocks, Calorimetry, Condensations, Coupling reactions, Epimerizations, PEGylations, Peptide synthesis, Racemizations, Solid phase peptide synthesis, Solvents

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