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718750 Sigma-Aldrich

BrettPhos Pd G1, Methyl t-Butyl Ether Adduct

may contain up to 1 mole equivalent of MTBE, 97%

Synonym: (BrettPhos) palladium(II) phenethylamine chloride, BrettPhos Palladacycle, BrettPhos precatalyst, Chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′, 6′-triisopropyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II)

  • Empirical Formula (Hill Notation) C43H63ClNO2PPd

  • Molecular Weight 798.81

  •  PubChem Substance ID 329763603




1, 5 g in glass bottle

100 mg in glass bottle


Application Guide for Palladium Catalyzed Cross-Coupling Reactions

Catalyst for:
• C,N-cross coupling of unprotected 3-halo-2-aminopyridines with primary and secondary amines
• Amination reaction
• N-arylation of aminophenols

General description

BrettPhos Pd G1 is a Buchwald first generation (G1) palladacycle precatalyst that can be used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. The formation of the active Pd(0) species in the G1 precatalyst is easy to generate, requiring merely a deprotonation with a base. The resulting catalyst is very active, even at temperatures down to −40 °C, and can be used in a variety of cross-coupling protocols.

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
NONH for all modes of transport
WGK Germany 
Protocols & Articles


Palladium-catalyzed coupling of functionalized primary and secondary amines with aryl and heteroaryl halides: two ligands suffice in most cases

We report our studies on the use of two catalyst systems, based on the ligands BrettPhos and RuPhos, which provide the widest scope for Pd-catalyzed C-N cross-coupling reactions to date. Often low ca...
Keywords: Arylations, Catalysis, Coupling reactions, Cross couplings, Ligands, Pharmaceutical

Stephen Buchwald Group – Professor Product Portal

From our library of Articles, Sigma-Aldrich presents Stephen Buchwald Group – Professor Product Portal
Keywords: Aminations, Asymmetric catalysis, Asymmetric synthesis, Catalysis, Coupling reactions, Cross couplings, Fluorinations, Ligands, Solvents, transformation

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Buchwald Precatalysts and Ligand Guide

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Peer-Reviewed Papers


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