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731129 Sigma-Aldrich

N-Isopropylacrylamide

≥99%

Synonym: NIPAM

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Properties

Related Categories Acrylamide and Methacrylamide, Acrylic Monomers, Materials Science, Monomers, Polymer Science More...
Quality Level   100
assay   ≥99%
bp   89-92 °C/2 mmHg (lit.)
mp   60-63 °C (lit.)
  63-67 °C
storage temp.   2-8°C
SMILES string   CC(C)NC(=O)C=C
InChI   1S/C6H11NO/c1-4-6(8)7-5(2)3/h4-5H,1H2,2-3H3,(H,7,8)
InChI key   QNILTEGFHQSKFF-UHFFFAOYSA-N

Description

General description

N-Isopropylacrylamide (NIPAM) is a biocompatible monomeric unit that can be used in the formation of stimuli responsive polymers due to its temperature sensitive properties. These properties include temperature based volumetric and phase changes, which change when the temperature of the solution reaches a lower critical solution temperature (LCST).

Application

NIPAM can be used to prepare poly(NIPAM) for a variety of applications such as tissue engineering, cell culture, biomedical coating, drug delivery, and muscle regeneration.

Packaging

5, 25 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
AS3675000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Poly(N-isopropylacrylamide)-based Smart Surfaces for Cell Sheet Tissue Engineering

Tissue engineering has become a key therapeutic tool in the treatment of damaged or diseased organs and tissues, such as blood vessels and urinary bladders.1 Nonetheless, major challenges still need ...
Masamichi NakayamaTeruo Okano and Françoise M. Winnik
Material Matters 2010, 5.3, 56.
Keywords: Adhesion, Biomaterials, Cell culture, Clinical, Dehydration reaction, Growth factors, Hydration reaction, Immobilization, Inflammation, Ligands, Magnetic resonance spectroscopy, Polymerization reactions, Radical polymerization, Rearrangements, Reversible addition-fragmentation chain transfer polymerizations, Solvents

Related Content

NIPAM based Polymers

Stimuli-responsive polymers, also known as “smart” polymers or “environmentally sensitive” polymers, undergo rapid changes in their microstructure from a hydrophilic to a hydrophobic state, triggered...
Keywords: Adsorption, Bacterial conjugations, Biological processes, Separation

Peer-Reviewed Papers
15

References

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