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735353 Sigma-Aldrich

Lithium 2,2,6,6-tetramethylpiperidide

97%

Synonym: 2,2,6,6-Tetramethylpiperidine lithium salt (1:1), LTMP

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Properties

Related Categories Acids & Bases, Bases, Chemical Synthesis, Organic Bases, Synthetic Reagents More...
InChI Key   ANYSGBYRTLOUPO-UHFFFAOYSA-N
assay   97%

Description

Application

Lithium 2,2,6,6-tetramethylpiperidide is a strong base and can be used:
• For the synthesis of enamines from terminal epoxides through trans-α-lithiated epoxide as an intermediate.
• For ortholithiation of arenes such as 1,3-bis(trifluoromethyl)benzene, 4,4-dimethyl-2-phenyl-2-oxazoline, 1,4-bis(trifluoromethyl)benzene and 1,3-dimethoxybenzene.
• In combination with Lewis donor ligand, N,N,N′,N′-tetramethylethylenediamine (TMEDA) for deprotonative metalation of methoxy-substituted arenes.{21]

Packaging

10, 25 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 3131 8(4.3) / PGII
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles

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Peer-Reviewed Papers
15

References

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