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740705 Sigma-Aldrich

Poly(ethylene glycol) methyl ether 2-(dodecylthiocarbonothioylthio)-2-methylpropionate

average Mn 1,100

Synonym: Methoxy poly(ethylene oxide)-2-(dodecylthiocarbonothioylthio)-2-methylpropionate, PEG DDMAT macroCTA

  •  NACRES NA.23

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Properties

Related Categories Macro-RAFT Agents, Materials Science, Monofunctional PEGs, Poly(ethylene glycol) and Poly(ethylene oxide), Polymer Science,
Quality Level   100
form   liquid
  semisolid
  solid
mol wt   average Mn 1,100
transition temp   Tm 22-27 °C
PDI   ≤1.1
Ω-end   DDMAT
α-end   methoxy
polymer architecture   shape : linear
functionality : monofunctional
reaction suitability   reagent type: chemical modification reagent
reaction type: Polymerization Reactions

Description

General description

Need help choosing the correct RAFT Agent? Please consult the RAFT Agent to Monomer compatibility table.

Molecular weight: PEG Average Mn ~750 kDa; n ~17

Packaging

1 g in glass bottle

Application

RAFT agent for controlled radical polymerization; especially suited for the polymerization of styrene; acrylate and acrylamide monomers to make lithographically and biologically important PEG-block copolymers. Chain Transfer Agent (CTA)

Legal Information

Sold for research purposes only: See sigma-aldrich.com/raftlicense. Patents: WO98/01478; WO99/311444.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
RIDADR 
UN 3335
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

A micro review of reversible addition/fragmentation chain transfer (RAFT) polymerization

Reversible addition/fragmentation chain transfer (RAFT) polymerization is a reversible deactivation radical polymerization (RDRP) and one of the more versatile methods for providing living characteri...
Keywords: Biomaterials, Living polymerization, Nanotechnology, Polymerization reactions, Radical polymerization, Reversible addition-fragmentation chain transfer polymerizations, transformation

Applying ARGET ATRP to the Growth of Polymer Brush Thin Films by Surface-initiated Polymerization

In 2006, Matyjaszewski and co-workers first described controlled radical polymerization by Activators ReGenerated by Electron Transfer Atom Transfer Radical Polymerization (ARGET ATRP),1-3 a developm...
Keywords: Antimicrobials, Ligands, Nanotubes, Oxidations, Polymerization reactions, Radical polymerization, Reductions, Reversible addition-fragmentation chain transfer polymerizations, Solution polymerization, Solvents

Cell Culture Scaffolds via Bio-orthogonal Click Reactions

1,2Malar A. Azagarsamy, 1Navakanth R. Gandavarapu, 1,2Kristi S. Anseth* 1Department of Chemical and Biological Engineering and 2the Howard Hughes Medical Institute, University of Colorado at Boulder,...
Keywords: Addition reactions, Adhesion, Biomaterials, Catalysis, Cell culture, Cell signaling, Chemical reactions, Click chemistry, Cycloadditions, Degradations, Growth factors, Huisgen Cycloaddition, Ligands, Michael Addition, Peptide synthesis, Polymerization reactions, Step-growth polymerization

Concepts and Tools for RAFT Polymerization

Reversible addition/fragmentation chain transfer (RAFT) is a form of living radical polymerization. RAFT polymerization was discovered at CSIRO in 1998.1 It soon became the focus of intensive researc...
Keywords: Polymerization reactions, Radical polymerization, Reversible addition-fragmentation chain transfer polymerizations

Copper(I)-mediated Living Radical Polymerization in the Presence of Pyridylmethanimine Ligands

Emergence of living radical polymerization mediated by transition metal catalysts in 1995 was a seminal piece of work in the field of synthetic polymer chemistry.1-3 Since this date, many transition ...
Keywords: Catalysis, Condensations, Evaporation, Filtration, Ligands, Oxidations, Polymer science, Polymerization reactions, Precipitation, Purification, Radical polymerization, Reductions, Solvents

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. For decades, research in polymeric biomateria...
Keywords: Absorption, Angiogenesis, Biomaterials, Catalysis, Cell culture, Degradations, Eliminations, Growth factors, Infrared spectroscopy, Ligands, Michael Addition, Polymerization reactions, Ring-opening polymerization

Functional RAFT Polymers for Biomedical Applications

Reversible addition–fragmentation chain transfer (RAFT) polymerization is rapidly moving to the forefront in construction of drug and gene delivery vehicles. The RAFT technique allows unprecedented l...
M. Shahinur Rahman, Sebastian Grajales
Material Matters, 2016, 8.3, 96
Keywords: Bacterial conjugations, Building blocks, Catalysis, Click chemistry, Cycloadditions, Diagnostic, Diffusion, Environmental, Nanotechnology, Pharmaceutical, Polymerization reactions, Radical polymerization, Reductions, Reversible addition-fragmentation chain transfer polymerizations, Solvents

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Carmen Scholz Department of Chemistry, University of Alabama in Huntsville Huntsville, AL 35899 Email: scholzc@uah.edu
Keywords: Addition reactions, Asymmetric synthesis, Building blocks, Catalysis, Degradations, Living polymerization, PEGylations, Polymerization reactions, Precipitation, Proteomics, Ring-opening polymerization, Solvents

Polyethylene Glycol (PEG) Selection Guide

Poly(ethylene glycol) (PEG) is a synthetic, hydrophilic, biocompatible polymer with widespread use in biomedical and other applications. PEGs are synthesized using a ring-opening polymerization of et...
Keywords: Adhesion, Bacterial conjugations, Click chemistry, Molecular biology, PEGylations, Polymerization reactions, Ring-opening polymerization

Protein and Peptide Polymer Conjugates

1Department of Chemistry, The University of Warwick, Coventry CV4 7AL, U.K. 2Warwick Medical School, The University of Warwick, Coventry CV4 7AL, U.K. 3Faculty of Pharmacy and Pharmaceutical Sciences...
Matthias Hartlieb,1 Raoul Peltier,1 Sébastien Perrier1,2,3*
Material Matters, 2017, 12.2
Keywords: Aminolysis, Bacterial conjugations, Biological processes, Biomaterials, Click chemistry, Cycloadditions, Degradations, Gene expression, Growth factors, Immobilization, Michael Addition, Nanotubes, PEGylations, Peptide synthesis, Pharmaceutical, Polymerization reactions, Post translational modifications, Purification, Radical polymerization, Reversible addition-fragmentation chain transfer polymerizations, Solid phase peptide synthesis, Solvents

Tools for Performing ATRP (Atom Transfer Radical Polymerization)

Controlled radical polymerization (CRP) techniques have been reviewed in a number of articles1,2 and books,3 and include nitroxide-mediated polymerization (NMP),4-7 reversible addition fragmentation ...
Sebastian Grajales
Keywords: Ligands, Polymerization reactions, Purification, Radical polymerization, Reversible addition-fragmentation chain transfer polymerizations, Solution polymerization

Typical Procedures for Polymerizing via ATRP

The following two procedures describe two ATRP polymerization reactions as performed by Prof. Dave Hadddleton′s research group at the University of Warwick.
Keywords: Gas chromatography, Ligands, Nuclear magnetic resonance spectroscopy, Polymerization reactions, Size-exclusion chromatography, Solvents

Typical Procedures for Polymerizing via RAFT

RAFT (Reversible Addition/Fragmentation Chain Transfer) is a form of living radical polymerization involving conventional free radical polymerization of a substituted monomer in the presence of a sui...
Keywords: Nuclear magnetic resonance spectroscopy, Polymerization reactions, Radical polymerization, Reversible addition-fragmentation chain transfer polymerizations

Peer-Reviewed Papers
15

References

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