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  • 741884 - Poly(2-ethyl-2-oxazoline)

741884 Aldrich


average Mn 25,000, PDI ≤1.4



Features and Benefits

Nonionic, water-soluble thermoplastic. Better heat stability than poly(vinyl alcohol). Good melt flow, shear stability and Newtonian characteristics. Water is a room temperature Theta solvent.


5 g in glass bottle


This Poly(2-ethyl-2-oxazoline) polymer is amorphous and water soluble with good temperature stability. Jordan and coworkers showed biocompatibility, no accumulation in tissue, and rapid clearance from the bloodstream1. End-group modified poly(2-ethyl-2-oxazoline)s have been conjugated to peptides2, and were shown as versatile alternatives to poly(ethylene glycol) (PEG) for both protein and small drug conjugation3.

Potential substitute for poly(vinyl alcohol) and poly(vinyl pyrrolidone). Sometimes it is used as an adhesion promoter in coatings. This is also sometimes used in heat sealing and remoistenable hot-melt adhesives. N-propionyl substituted linear polyethylenimine

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Protocols & Articles


Functional Polymers for Biomedical Applications

Wide range of functional polymers for biomedical applications have been synthesized and structurally characterized. Several classes of polymers including biodegradable polymers, hydrophilic & amphiph...
Gangadhar Panambur, Donghun Koo, Philip Dimitrov, Shahinur Rehman, Bryce Nelson, Viktor Balema
Keywords: Biomaterials, Building blocks, Polymerization reactions, Reversible addition-fragmentation chain transfer polymerizations

Poly(2-Oxazoline)S: The Versatile Polymer Platform for Biomedicine

Victor R. de la Rosa,1 An Van Den Bulcke,2 and Richard Hoogenboom1* 1Supramolecular Chemistry Group, Department of Organic and Macromolecular Chemistry Ghent University, Krijgslaan 281-S4, 9000 Ghent...
Victor R. de la Rosa, An Van Den Bulcke, and Richard Hoogenboom
Material Matters, 2016, 11.3
Keywords: Adhesion, Adsorption, Amidations, Bacterial conjugations, Biomaterials, Cancer, Catalysis, Click chemistry, Clinical, Cosmetics, Cycloadditions, Degradations, Electron spin resonance, Pharmaceutical, Polymerization reactions, Ring-opening polymerization

Poly(2-oxazoline)s (POx) in Biomedical Applications

Robert Luxenhofer1 and Rainer Jordan2 1Functional Polymer Materials, Chair of Chemical Technology of Materials Synthesis, University Würzburg, Röntgenring 11, 97070 Würzburg, Germany 2Professur für M...
Robert Luxenhofer, Rainer Jordan
Material Matters, 2016, 8.3, 70
Keywords: Biomaterials, Cancer, Clinical, Degradations, Melting, PEGylations, Polymerization reactions, Solvents, Transfection

Peer-Reviewed Papers


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