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746118 Sigma-Aldrich

Sodium difluoroheptylazidosulfinate

95%

Synonym: Baran DAAS-Na Reagent, Sodium 1,1-difluoro-7-azido-heptylsulfinate, Sodium 7-azido-1,1-difluoroheptanesulfinate

  • CAS Number 1450912-63-6

  • Empirical Formula (Hill Notation) C7H12F2N3NaO2S

  • Molecular Weight 263.24

  •  PubChem Substance ID 329765744

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Properties

Related Categories Baran Diversinates, Bifunctional Linker Diversinates, C-H Activation, Catalysis and Inorganic Chemistry, Chemical Synthesis,
InChI Key   FFNHIEJQAMGBCZ-UHFFFAOYSA-M
assay   95%
reaction suitability   reagent type: linker
storage temp.   2-8°C

Description

Application

Within heteroarene platforms, DAAS-Na allows for the direct introduction of a difluoroalkyl chain carrying an azide group, which is designed for the purpose of bioconjugation. Through a Huisgen cycloaddition (a "click" reaction), the azide moiety can then be reacted with a terminal alkyne that is bound to a functional molecule such as biomacromolecules. This effectively allows for a covalent linkage between a heteroarene and any target molecule, for example, between a heteroarene-containing drug and an antibody. This reagent was developed by the Baran Group and is one of several reagents for the direct alkylation of heterocycles.

Learn More at the Professor and Product Portal of Professor Phil S. Baran.

Packaging

100 mg in glass insert

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles

Articles

Diversinates™: Linkers for Native Chemical Tagging of C–H Bonds

Bioconjugation is an essential concept in chemical biology wherein a biomolecule is covalently bound to another biomolecule, a fluorescent dye, a cytotoxic payload (drug), and other bioactive or labe...
Keywords: Chemical biology, PAGE

Professor Product Portal - Baran Group

From our library of Articles, Sigma-Aldrich presents Professor Product Portal - Baran Group
Keywords: Building blocks, Fluorinations, Oxidations, Pharmaceutical

Peer-Reviewed Papers
15

References

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