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  • 757810 - Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid

757810 Sigma-Aldrich

Poly(ethylene glycol) 2-mercaptoethyl ether acetic acid

average Mn 1,000

Synonym: mercaptoPEG acid, mercaptopoly(ethylene glycol) carboxylic acid, mercaptopolyoxyethylene acetic acid, thio-PEG, thiol-PEG-carboxylate, thiol-PEG-acid

  • CAS Number 165729-81-7

  • Linear Formula HSC2H4O(C2H4O)nCH2CO2H

  •  NACRES NA.23



Related Categories COOH Functionalized, COOH-PEG-Thiol (COOH-PEG-SH), Heterobifunctional PEGs, Materials Science, Poly(ethylene glycol) and Poly(ethylene oxide),
mol wt   PEG average Mn 1,000 (n~22)
  average Mn 1,000
transition temp   Tm 40-45 °C
Ω-end   thiol
α-end   carboxylic acid
polymer architecture   shape : linear
functionality : heterobifunctional
reaction suitability   reagent type: cross-linking reagent
reactivity: amine reactive
  reagent type: cross-linking reagent
reactivity: thiol reactive
storage temp.   −20°C



500 mg in glass insert


• bioconjugation
• drug delivery
• PEG hydrogel
• crosslinker
• surface functionalization

Reported applications include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
604.4 °F
Flash Point(C) 
> 318 °C


Certificate of Analysis (COA)

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Protocols & Articles


Cell Culture Scaffolds via Bio-orthogonal Click Reactions

1,2Malar A. Azagarsamy, 1Navakanth R. Gandavarapu, 1,2Kristi S. Anseth* 1Department of Chemical and Biological Engineering and 2the Howard Hughes Medical Institute, University of Colorado at Boulder,...
Keywords: Addition reactions, Adhesion, Biomaterials, Catalysis, Cell culture, Cell signaling, Chemical reactions, Click chemistry, Cycloadditions, Degradations, Growth factors, Huisgen Cycloaddition, Ligands, Michael Addition, Peptide synthesis, Polymerization reactions, Step-growth polymerization

Injectable Hydrogels for Cell Delivery and Tissue Regeneration

Prathamesh M. Kharkar,1 April M. Kloxin1,2* 1Materials Science and Engineering and 2Chemical and Biomolecular Engineering University of Delaware, Newark, DE 19716 USA *Email: akloxin@udel.edu
Keywords: Addition reactions, Adhesion, Angiogenesis, Biochemistry, Biomaterials, Building blocks, Cardiovascular, Catalysis, Cell proliferation, Click chemistry, Clinical, Cycloadditions, Degradations, Growth factors, Reversed-phase chromatography

Polyethylene Glycol (PEG) Selection Guide

Poly(ethylene glycol) (PEG) is a synthetic, hydrophilic, biocompatible polymer with widespread use in biomedical and other applications. PEGs are synthesized using a ring-opening polymerization of et...
Keywords: Adhesion, Bacterial conjugations, Click chemistry, Molecular biology, PEGylations, Polymerization reactions, Ring-opening polymerization

Peer-Reviewed Papers


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