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  • 757853 - Poly(ethylene glycol) (N-hydroxysuccinimide 5-pentanoate) ether N′-(3-maleimidopropionyl)aminoethane

757853 Sigma-Aldrich

Poly(ethylene glycol) (N-hydroxysuccinimide 5-pentanoate) ether N′-(3-maleimidopropionyl)aminoethane

average Mn 4,000

Synonym: Maleimide polyoxyethylene NHS-protected valeric acid, Maleimide-PEG-NHS protected acid, Maleimide-PEG-acid, maleimide-PEG-valeric acid

  • CAS Number 851040-94-3

  • Linear Formula C7H7N2O3(C2H4O)nC9H12NO4

  •  NACRES NA.23



Related Categories Heterobifunctional PEGs, Maleimide Functionalized, Maleimide-PEG-NHS Ester, Materials Science, NHS Ester Functionalized,
Quality Level   100
mol wt   average Mn 4,000
transition temp   Tm 46-51 °C
Ω-end   NHS ester
α-end   maleimide
polymer architecture   shape : linear
functionality : heterobifunctional
reaction suitability   reagent type: cross-linking reagent
reactivity: amine reactive
  reagent type: cross-linking reagent
reactivity: thiol reactive
storage temp.   −20°C


General description

PEG average Mn 3,400; n~77


100 mg in glass insert


Applications have been reported for: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Protocols & Articles


Cell Culture Scaffolds via Bio-orthogonal Click Reactions

1,2Malar A. Azagarsamy, 1Navakanth R. Gandavarapu, 1,2Kristi S. Anseth* 1Department of Chemical and Biological Engineering and 2the Howard Hughes Medical Institute, University of Colorado at Boulder,...
Keywords: Addition reactions, Adhesion, Biomaterials, Catalysis, Cell culture, Cell signaling, Chemical reactions, Click chemistry, Cycloadditions, Degradations, Growth factors, Huisgen Cycloaddition, Ligands, Michael Addition, Peptide synthesis, Polymerization reactions, Step-growth polymerization

Injectable Hydrogels for Cell Delivery and Tissue Regeneration

Prathamesh M. Kharkar,1 April M. Kloxin1,2* 1Materials Science and Engineering and 2Chemical and Biomolecular Engineering University of Delaware, Newark, DE 19716 USA *Email: akloxin@udel.edu
Keywords: Addition reactions, Adhesion, Angiogenesis, Biochemistry, Biomaterials, Building blocks, Cardiovascular, Catalysis, Cell proliferation, Click chemistry, Clinical, Cycloadditions, Degradations, Growth factors, Reversed-phase chromatography

Polyethylene Glycol (PEG) Selection Guide

Poly(ethylene glycol) (PEG) is a synthetic, hydrophilic, biocompatible polymer with widespread use in biomedical and other applications. PEGs are synthesized using a ring-opening polymerization of et...
Keywords: Adhesion, Bacterial conjugations, Click chemistry, Molecular biology, PEGylations, Polymerization reactions, Ring-opening polymerization

Peer-Reviewed Papers


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