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765090 Sigma-Aldrich

Polyethylenimine, linear

average Mn 10,000, PDI ≤1.3

Synonym: PEI

  • CAS Number 9002-98-6

  • Linear Formula (CH2CH2NH)n

  •  NACRES NA.23



Related Categories Hydrophilic Polymers, Linear PEI, Materials Science, Poly(2-oxazoline) and Polyethylenimine (PEI), Polyethylenimine (PEI),
Quality Level   100
mol wt   average Mn 10,000
mp   48-53 °C
PDI   ≤1.3
storage temp.   2-8°C
InChI   1S/C2H5N/c1-2-3-1/h3H,1-2H2


General description

Polyethylenimine (linear) is a versatile cationic polymer with a high transfection efficiency. It is used as a gene delivery reagent. It is a non-lipid polycation that can be used to transfect oligonucleotides and plasmid into cells in vitro and in vivo.


1 g in glass bottle

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable


Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles


Delivery of Nucleic Acids Using Polymers

The medical application of molecular nanotechnology, referred to as “nanomedicine,” is believed to lead to progress in human therapeutics in terms of improving health at the molecular scale.1 This ha...
Olivia Merkel
Material Matters, 2016, 8.3, 74
Keywords: AGE, Adhesion, Bacterial conjugations, Cancer, Catalysis, Clinical, Degradations, Evaporation, Functional genomics, Gene expression, Genetic, Genomics, Growth factors, Immobilization, Ligands, Methylations, Nanotechnology, PEGylations, Pharmaceutical, Purification, Respiratory, Transcription, Transfection

Functional Polymers for Biomedical Applications

By: Gangadhar Panambur, Donghun Koo, Philip Dimitrov, Shahinur Rehman, Bryce Nelson, Viktor Balema

Keywords: Biomaterials, Building blocks, Polymerization reactions, Reversible addition-fragmentation chain transfer polymerizations

Functionalized Pei and Its Role in Gene Therapy

1Department of Pharmacy, Pharmaceutical Technology and Biopharmacy,  Ludwig-Maximilians-Universität München, Butenandtstraße 5, 81377  München, Germany 2Nanosystems Initiative Munich (NIM), Ludwig-Ma...
Bettina Schwarz,1 Olivia M. Merkel1,2*
Material Matters, 2017, 12.2
Keywords: Bacterial conjugations, Clinical, Condensations, Degradations, Diseases, Gene expression, Genetic, Infrared spectroscopy, Ligands, Michael Addition, Microscopy, Nanotubes, Pharmaceutical, Reductions, Substitutions, Transfection

Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting

Department of Chemistry and Biochemistry, Faculty of Engineering, Kyushu University, Japan *E-mail: ykatatcm@mail.cstm.kyushu-u.ac.jp
Keywords: Amplification, Angiogenesis, Biochemistry, Cancer, Cardiovascular, Clinical, Diagnostic, Electron spin resonance, Enzyme activity, Gene expression, Genetic, Infrared spectroscopy, Reductions, Transcription

Recent Progress on Nonviral Delivery Carriers for CRISPR/Cas9 Systems

State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials of Ministry of Education, College of Chemistry, Nankai University, National Demonstration Center for...
Keywords: Adsorption, Chemical biology, Clinical, Combinatorial library, Condensations, Degradations, Gene expression, Gene knockdown, Ligands, Metal organic frameworks, Transfection

Peer-Reviewed Papers


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