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765376 Sigma-Aldrich

Gold nanoparticles

30 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H2O

Synonym: Au NP NH2, Gold Colloid, Gold nanoparticles NH2 functionalized

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Description

General description

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. Amine functionalized GNPs which have Poly Ethylene Glycol (PEG) as the ligand or carrier molecule forms a conjugate with siRNA and is extremely useful in RNAi technology. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.

Application

Functionalized particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Several other specific applications have been listed below:
• Since they adhere to cell membranes, AuNPs are used in cellular and intracellular targeting in targeted drug delivery applications and can also be used in biodistribution studies
• AuNPs may also be used in photothermal therapy and radiotherapy.
• Proposed applications of gold nanoparticles are as:drug delivery agents for cancer therapy, coatings, plastics, nanowire, nanofiber, textiles, catalyst applications.
•  They may also be used in carrying siRNA which acts against human prostate carcinoma cells by inhibiting a specific cancer gene.

Packaging

1 mL in poly bottle

Features and Benefits

• A Negatively charged siRNA-PEG complex attached to positively charged GNPs is easily cleavable in reductive cytosolic environment thus enabling the release of siRNA into cytosol.
• The PEG coating decreases the cytotoxicity and increases efficiency of GNPs. PEG increases the stability of the nanoparticles and prevents agglomeration.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

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Protocols & Articles

Articles

Magnetic Nanoparticles for Cancer Theranostics

Saumya Nigam,1 Lina Pradhan,2 and D. Bahadur*3 1IITB-Monash Research Academy, IIT Bombay, Powai, Mumbai, India 2Centre for Research in Nanotechnology & Science IIT Bombay, Powai, Mumbai, India 3Depar...
Keywords: Apoptosis, Bacterial conjugations, Cancer, Diagnostic, Magnetic resonance imaging, Materials Science, Nanomaterials, Nanotechnology, Reductions

Micro- and Nanofabricated Biomaterials for the Study of Cells and Microtissues

Phin Peng Lee, Karen E. Samy, Miquella G. Chavez, Alec Cerchiari, Tejal A. Desai* Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 9415...
Keywords: Absorption, Adhesion, Amplification, Apoptosis, Biomaterials, Cancer, Cell culture, Cell proliferation, Diffusion, Immobilization, Indicators, Infrared spectroscopy, Ligands, Magnetic resonance imaging, Materials Science, Microscopy, Molecular biology, Nanotechnology, Semiconductor, Solvents

Peer-Reviewed Papers
15

References

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