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765511 Sigma-Aldrich

Gold nanoparticles

20 nm diameter, carboxylic acid functionalized, PEG 5000 coated, OD 50, dispersion in H2O

Synonym: Au NP COOH, Gold Colloid, Gold nanoparticles COOH functionalized

  •  NACRES NA.23

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Properties

Related Categories Bioelectronics, Biosensing and Bioimaging, Functionalized Gold Nanoparticles, Gold Nanoparticles, Materials Science,
material   PEG 5000
form   dispersion in H2O
  nanoparticles
packaging   poly bottle of 1 mL
OD   50
diameter   20 nm
pH   6.0-8.0 (25 °C)
solubility   water: miscible
density   1.00 g/cm3
λmax   520 nm
functional group   carboxyl
storage temp.   2-8°C

Description

General description

Carboxylic acid functionalized GNPs form conjugates with various protein molecules due to the electrostatic attraction between negatively charged carboxylate groups and positively charged amino groups of protein.

Application

Carboxylic acid functionalized, PEG 5000 coated, OD 50, and H2O dispersed gold nanoparticles can be potentially used in the development of biosensors, cancer-cell imaging, drug delivery, and photothermal therapy.
AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique. It may also be used in the immobilization of antibodies to improve the sensitivity of optical fiber sensors for the screening of COVID-19. It can also be deposited on the titanium electrode for the formation of a miniaturized device for the electrochemical detection of DNA hybridization.

The carboxylic acid group binds with various proteins and can be used in targeted drug delivery and gene therapy.

Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Packaging

1 mL in poly bottle

Features and Benefits

Decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. The PEG increases the stability of the nanoparticles and prevents agglomeration.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Increasing the Sensitivity of Lateral Flow Diagnostic Assays with Ultra-Bright Gold Nanoshell Reporters

Lateral flow assays (also known as immunochromatographic assays) detect or quantify biomolecules in complex samples including blood, urine, saliva, or other fluids to diagnose a variety of medical co...
Keywords: Absorption, Adsorption, Bacterial conjugations, Centrifugation, Deposition, Detergents, Diagnostic, Filtration, Flow cytometry, Hormones, Hydration reaction, Immobilization, Ligands, Microscopy, Raman spectroscopy, Scanning electron microscopy, Spectroscopy, Transmission electron microscopy

Peer-Reviewed Papers
15

References

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