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765589 Sigma-Aldrich

Gold nanoparticles

50 nm diameter, carboxylic acid functionalized, PEG 5000 coated, dispersion in H2O

Synonym: Au NP COOH, Gold Colloid, Gold nanoparticles COOH functionalized

  •  NACRES NA.23

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Properties

Related Categories Bioelectronics, Biosensing and Bioimaging, Functionalized Gold Nanoparticles, Gold Nanoparticles, Materials Science,
material   PEG 5000
form   dispersion in H2O
  nanoparticles
packaging   poly bottle of 1 mL
OD   50
diameter   50 nm
pH   6.0-8.0 (25 °C)
solubility   water: miscible
density   1.00 g/cm3
λmax   535 nm
functional group   carboxyl
storage temp.   2-8°C

Description

General description

Carboxylic acid functionalized GNPs forms conjugates with various protein molecules due to the electrostatic attraction between negatively charged carboxylate groups and positively charged amino groups of protein.

Application

Gold nanoparticles 50 nm diameter, carboxylic acid functionalized, PEG 5000 coated, dispersion in H2O can be potentially used in the development of biosensors, cancer-cell imaging, drug delivery, and photothermal therapy.
AuNPs may also be used in the immobilization of antibodies to improve the sensitivity of optical fiber sensors for the screening of COVID-19. It can also be deposited on the titanium electrode for the formation of a miniaturized device for the electrochemical detection of DNA hybridization.

The carboxylic acid group binds with proteins and is used in targeted drug delivery and gene therapy.

Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Packaging

1 mL in poly bottle

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Increasing the Sensitivity of Lateral Flow Diagnostic Assays with Ultra-Bright Gold Nanoshell Reporters

Lateral flow assays (also known as immunochromatographic assays) detect or quantify biomolecules in complex samples including blood, urine, saliva, or other fluids to diagnose a variety of medical co...
Keywords: Absorption, Adsorption, Bacterial conjugations, Centrifugation, Deposition, Detergents, Diagnostic, Filtration, Flow cytometry, Hormones, Hydration reaction, Immobilization, Ligands, Microscopy, Raman spectroscopy, Scanning electron microscopy, Spectroscopy, Transmission electron microscopy

Magnetic Nanoparticles for Cancer Theranostics

Saumya Nigam,1 Lina Pradhan,2 and D. Bahadur*3 1IITB-Monash Research Academy, IIT Bombay, Powai, Mumbai, India 2Centre for Research in Nanotechnology & Science IIT Bombay, Powai, Mumbai, India 3Depar...
Keywords: Apoptosis, Bacterial conjugations, Cancer, Diagnostic, Magnetic resonance imaging, Materials Science, Nanomaterials, Nanotechnology, Reductions

Micro- and Nanofabricated Biomaterials for the Study of Cells and Microtissues

Phin Peng Lee, Karen E. Samy, Miquella G. Chavez, Alec Cerchiari, Tejal A. Desai* Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 9415...
Keywords: Absorption, Adhesion, Amplification, Apoptosis, Biomaterials, Cancer, Cell culture, Cell proliferation, Diffusion, Immobilization, Indicators, Infrared spectroscopy, Ligands, Magnetic resonance imaging, Materials Science, Microscopy, Molecular biology, Nanotechnology, Semiconductor, Solvents

Peer-Reviewed Papers
15

References

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