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765708 Sigma-Aldrich

Gold nanoparticles

15 nm diameter, OD 50, methyl terminated, PEG 5000 coated, dispersion in H2O

Synonym: Au NP OMe, Gold Colloid, Gold nanoparticles OMe terminated

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Properties

Related Categories Bioelectronics, Biosensing and Bioimaging, Functionalized Gold Nanoparticles, Gold Nanoparticles, Materials Science,
material   PEG 5000
form   dispersion in H2O
  nanoparticles
packaging   poly bottle of 1 mL
OD   50
diameter   15 nm
pH   6.0-8.0 (25 °C)
solubility   water: miscible
density   1.00 g/cm3
λmax   520 nm
functional group   methoxy
storage temp.   2-8°C

Description

General description

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. AuNPs are shown to be highly sensitive colloidal biosensors. The poly (ethylene) glycol (PEG) coating on gold nanoparticles helps in the reduction of protein adsorption, reduces nonspecific interactions with cells and greatly improves the pharmokinetics of these nanoparticles and disables aggregation of the nanoparticles.PEG layer density depends inversely on the AuNP curvature. AuNPs coated with PEG 5000 exhibited the highest colloidal stability. The methyl group, being hydrophobic acts as a protecting shield between the gold nanoparticles and the hydrophilic outer PEG coating and also leads to a further reduction of protein adsorption and macrophage uptake by the AuNPs.

Application

Several other specific applications have been listed below:
• Since they adhere to cell membranes, AuNPs may find use in cellular and intracellular targeting in targeted drug delivery applications and may also used in biodistribution studies.
• AuNPs may also be used in photothermal therapy and radiotherapy.
• AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen, when injected intravenously in rats.Whereas, 10 nm nanoparticles were distributed more broadly into various organs.

Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Packaging

1 mL in poly bottle

Features and Benefits

PEG decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. PEG increases the stability of the nanoparticles and prevents agglomeration. Forms complexes easily with dyes and thiol ligands.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Increasing the Sensitivity of Lateral Flow Diagnostic Assays with Ultra-Bright Gold Nanoshell Reporters

Lateral flow assays (also known as immunochromatographic assays) detect or quantify biomolecules in complex samples including blood, urine, saliva, or other fluids to diagnose a variety of medical co...
Keywords: Absorption, Adsorption, Bacterial conjugations, Centrifugation, Deposition, Detergents, Diagnostic, Filtration, Flow cytometry, Hormones, Hydration reaction, Immobilization, Ligands, Microscopy, Raman spectroscopy, Scanning electron microscopy, Spectroscopy, Transmission electron microscopy

Micro- and Nanofabricated Biomaterials for the Study of Cells and Microtissues

Phin Peng Lee, Karen E. Samy, Miquella G. Chavez, Alec Cerchiari, Tejal A. Desai* Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 9415...
Keywords: Absorption, Adhesion, Amplification, Apoptosis, Biomaterials, Cancer, Cell culture, Cell proliferation, Diffusion, Immobilization, Indicators, Infrared spectroscopy, Ligands, Magnetic resonance imaging, Materials Science, Microscopy, Molecular biology, Nanotechnology, Semiconductor, Solvents

Peer-Reviewed Papers
15

References

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