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765732 Sigma-Aldrich

Gold nanoparticles

30 nm diameter, methyl terminated, PEG 5000 coated, OD 50, dispersion in H2O

Synonym: Au NP OMe, Gold Colloid, Gold nanoparticles OMe terminated

  •  NACRES NA.23

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Properties

Related Categories Bioelectronics, Biosensing and Bioimaging, Functionalized Gold Nanoparticles, Gold Nanoparticles, Materials Science,
material   PEG 5000
form   dispersion in H2O
  nanoparticles
packaging   glass bottle of 1 mL
OD   50
diameter   30 nm
pH   6.0-8.0 (25 °C)
solubility   water: miscible
density   1.00 g/cm3
λmax   525 nm
functional group   methoxy
storage temp.   2-8°C

Description

General description

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields.They show excellent biocompatibility and attractive physicochemical properties. AuNPs, as aggregates, are shown to be highly sensitive colloidal biosensors. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and disables aggregation of the nanoparticles. PEG layer density depends inversely on the AuNPs curvature. Denser coating was possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. The methyl group, being hydrophobic, acts as a protecting shield between the gold nanoparticles and the hydrophilic outer PEG coating and also leads to a further reduction of protein adsorption and macrophage uptake by the AuNPs.

Application

Several other specific applications have been listed below:
• Since they adhere to cell membranes, AuNPs can be used in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.
• AuNPs can be used in photothermal therapy and radiotherapy.
• Studies show that 30-nm PEG-coated AuNPs have been successfully used to deliver tumor necrosis factor to solid tumors.

Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Packaging

1 mL in glass bottle

Features and Benefits

Decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. PEG increases the stability of the nanoparticles and prevents agglomeration. Forms complexes easily with dyes and thiol ligands.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Increasing the Sensitivity of Lateral Flow Diagnostic Assays with Ultra-Bright Gold Nanoshell Reporters

Lateral flow assays (also known as immunochromatographic assays) detect or quantify biomolecules in complex samples including blood, urine, saliva, or other fluids to diagnose a variety of medical co...
Keywords: Absorption, Adsorption, Bacterial conjugations, Centrifugation, Deposition, Detergents, Diagnostic, Filtration, Flow cytometry, Hormones, Hydration reaction, Immobilization, Ligands, Microscopy, Raman spectroscopy, Scanning electron microscopy, Spectroscopy, Transmission electron microscopy

Magnetic Nanoparticles for Cancer Theranostics

Saumya Nigam,1 Lina Pradhan,2 and D. Bahadur*3 1IITB-Monash Research Academy, IIT Bombay, Powai, Mumbai, India 2Centre for Research in Nanotechnology & Science IIT Bombay, Powai, Mumbai, India 3Depar...
Keywords: Apoptosis, Bacterial conjugations, Cancer, Diagnostic, Magnetic resonance imaging, Materials Science, Nanomaterials, Nanotechnology, Reductions

Micro- and Nanofabricated Biomaterials for the Study of Cells and Microtissues

Phin Peng Lee, Karen E. Samy, Miquella G. Chavez, Alec Cerchiari, Tejal A. Desai* Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA 9415...
Keywords: Absorption, Adhesion, Amplification, Apoptosis, Biomaterials, Cancer, Cell culture, Cell proliferation, Diffusion, Immobilization, Indicators, Infrared spectroscopy, Ligands, Magnetic resonance imaging, Materials Science, Microscopy, Molecular biology, Nanotechnology, Semiconductor, Solvents

Peer-Reviewed Papers
15

References

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