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766305 Sigma-Aldrich

Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite

95%

Synonym: Bis(2-cyanoethoxy)(diisopropylamino)phosphine, Bis(2-cyanoethoxy)-N,N-diisopropylaminophosphine

  • CAS Number 102690-88-0

  • Empirical Formula (Hill Notation) C12H22N3O2P

  • Molecular Weight 271.30

  •  MDL number MFCD00797597

  •  PubChem Substance ID 329767224

  •  NACRES NA.22

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Properties

Related Categories Chemical Biology, Chemical Synthesis, Coupling Reagents, Nucleoside Chemistry
Quality Level   100
assay   95%
refractive index   n20/D 1.465
density   1.039 g/mL at 25 °C
SMILES string   CC(C)N(C(C)C)P(OCCC#N)OCCC#N
InChI   1S/C12H22N3O2P/c1-11(2)15(12(3)4)18(16-9-5-7-13)17-10-6-8-14/h11-12H,5-6,9-10H2,1-4H3
InChI key   LDHWBEHZLFDXCU-UHFFFAOYSA-N

Description

General description

Useful phosphorylating reagent used in oligonucleotide synthesis for adding a terminal phosphate group to the 3′ or 5′ hydroxyl.

Application

Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite may be used as a phosphitylating agent during the multi-step synthesis of (-)-1L-chiro-inositol 2,3,5-trisphosphate starting from L-quebrachitol.

Packaging

1, 5 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2810 6.1 / PGIII
WGK Germany 
WGK 3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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