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771147 Sigma-Aldrich

1-Trifluoromethyl-1,2-benziodoxol-3-(1H)-one

60 wt. %, contains 40 wt. % Celatom® FW-80 as additive

Synonym: Togni Reagent II

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Properties

Related Categories Chemical Synthesis, Fluorination Reagents, Synthetic Reagents, Trifluoromethylation
Quality Level   100
contains   40 wt. % Celatom® FW-80 as additive
concentration   60 wt. %
mp   150-158 °C
storage temp.   2-8°C
SMILES string   FC(F)(F)[I]1OC(=O)c2ccccc12
InChI   1S/C8H4F3IO2/c9-8(10,11)12-6-4-2-1-3-5(6)7(13)14-12/h1-4H
InChI key   XHEOXSQMBWJOKP-UHFFFAOYSA-N

Description

Application

Electrophilic trifluoromethylating reagent has shown to be one of the more robust trifluoromethylation reagents on the market. However, a recent report has showed this product to have potential dangerous self-reactivity neat. We now offer a less self-reactive material mixed down in Celatom®, a silica-based adsorbent, which significantly reduces self-reactivity allowing for safer shipping and storage.

Packaging

1, 10 g in glass bottle

Legal Information

Celatom is a registered trademark of EP Minerals, LLC

Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Antonio Togni - Professor Product Portal

From our library of Articles, Sigma-Aldrich presents Antonio Togni - Professor Product Portal
Keywords: Asymmetric synthesis, Catalysis, Chemical biology, Herbicides, Hydrogenations, Ligands, Nuclear magnetic resonance spectroscopy, Spectroscopy

Baran Reagents FAQs

What do the Baran reagents do? Allow the placement of alkyl groups onto molecules in drug discovery by replacing a C-H bond with the corresponding C-C bond (trifluoromethyl, difluoromethyl, isopropyl...
Keywords: Agrochemicals, Alkylations, Drug discovery, Fluorinations, Liquid chromatography mass spectrometry, Medicinal chemistry, Nuclear magnetic resonance spectroscopy, PAGE, Solvents

Fluoroalkylation: Expansion of Togni Reagents

The installation of highly fluorinated groups into drug and pesticide candidates is a powerful strategy to modulate their properties. An incorporated fluorinated sidechain can tune the acidobasic beh...
Keywords: Catalysis, Chlorinations, Cyclizations, Degradations, Fluorinations, Grignard Reaction, Pesticides, Radical cyclization

Peer-Reviewed Papers
15

References

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