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778907 Sigma-Aldrich

(2-Hydroxypropyl)-β-cyclodextrin

Produced by Wacker Chemie AG, Burghausen, Germany, Life Science

Synonym: Cavasol® W7 HP

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Properties

Related Categories Chelation/Complexation Compounds, Chemical Synthesis, Cyclodextrins, Synthetic Reagents
Quality Level   100
grade   Produced by Wacker Chemie AG, Burghausen, Germany, Life Science
extent of labeling   0.59-0.73 molar substitution
impurities   ≤0.1% related substances, any (Ph Eur)
  ≤0.5% propylene glycol (Ph Eur)
  ≤1.0% β-dex (Ph Eur)
  ≤1.0% related substances, total other
  ≤1.0 ppm propylene oxide
loss   ≤10.0% loss on drying
conductivity   ≤200 μS/cm (Ph Eur)
suitability   clear, colorless for appearance of solution
  positive for identity
SMILES string   CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O

Description

Application

(2-Hydroxypropyl)-β-cyclodextrin can be used:
• In the preparation of imidazole nucleosides via enzymatic transglycosylation to improve the solubility and/or stability of 4-aryl and 4-heteroaryl-1H-imidazole reactants.
• Cyanazine-hydroxypropyl-β-cyclodextrin inclusion complex with enhanced water solubility when compared to cyanazine.

The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.

Legal Information

Cavasol is a registered trademark of Wacker Chemie AG

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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