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778966 Sigma-Aldrich

(2-Hydroxypropyl)-β-cyclodextrin

produced by Wacker Chemie AG, Burghausen, Germany

Synonym: (2-Hydroxypropyl)-beta-cyclodextrin, Cavasol® W7 HP, HP-β-CD

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Properties

Related Categories Chelation/Complexation Compounds, Chemical Synthesis, Cyclodextrins, Synthetic Reagents
grade   produced by Wacker Chemie AG, Burghausen, Germany
extent of labeling   molar substitution per 0.60
impurities   ≤1.0% unsubstituted cyclodextrin
  ≤5.0% polypropylene glycol
ign. residue   ≤2.5%
loss   ≤7.0% loss on drying
SMILES string   CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O
InChI key   ODLHGICHYURWBS-RYJYQAAZSA-N

Description

Application

(2-Hydroxypropyl)-β-cyclodextrin is a β-cyclodextrin derivative with enhanced water solubility. It is used as a solubilizer and stabilizer in pharmaceutical formulations. HP-β-CD also shows potent anticancer activity.

The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.

Legal Information

Cavasol is a registered trademark of Wacker Chemie AG

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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