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779229 Sigma-Aldrich

(2-Hydroxypropyl)-γ-cyclodextrin

Produced by Wacker Chemie AG, Burghausen, Germany, Life Science

Synonym: Cavasol® W8 HP, HGC

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Properties

Related Categories Chelation/Complexation Compounds, Chemical Synthesis, Cyclodextrins, Synthetic Reagents
Quality Level   200
grade   Produced by Wacker Chemie AG, Burghausen, Germany, Life Science
extent of labeling   0.5-0.7 molar substitution
impurities   ≤0.1% propylene glycol (Ph Eur)
loss   ≤10.0% loss on drying
pH   6-9 (2% in H2O)

Description

General description

(2-Hydroxypropyl)-γ-cyclodextrin (HP-β-CD) is a hydrophilic compound that can be used as a complexing agent to increase the aqueous solubility and dissolution rate of the drug molecule.

Application

HP-β-CD can be utilized to improve the aqueous solubility and dissolution rate of zolpidem (ZP) upon complexation. ZP-HP-β-CD complexes showed improved ataxic activity.
It is also used to enhance the wound healing property of curcumin by increasing the water solubility.

Legal Information

Cavasol is a registered trademark of Wacker Chemie AG

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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