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790184 Sigma-Aldrich

Sodium 1-(trifluoromethyl)cyclopropanesulfinate

Synonym: Baran TFCS-Na Reagent

  • Empirical Formula (Hill Notation) C4H4F3NaO2S

  • Molecular Weight 196.12

  •  MDL number MFCD28124332

  •  PubChem Substance ID 329768203

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Properties

Related Categories Baran Diversinates, C-H Activation, Catalysis and Inorganic Chemistry, Chemical Synthesis, Fluorinated Cyclic Diversinates,
InChI Key   IZLDENBRBYPDNY-UHFFFAOYSA-M
mp   287-292 °C

Description

Packaging

5 g in glass bottle

500 mg in amber glass bottle

Application

TFCS-Na is a diversification reagent for the C-H Functionalization of several classes of heterocycles. This reagent installs the trifluoromethylcyclopropyl group, which was recently reported to increase metabolic stability compared to compounds containing the tert-butyl group.

Simple Sulfinate Synthesis Enables C-H Trifluoromethylcyclopropanation

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Diversinates™: Any-Stage Functionalization of (Hetero)aromatic Scaffolds

The synthesis of heteroaromatic and aromatic compounds is at the heart of the chemical industry. With the ever-growing demand of new chemical entities coupled to the dwindling resources and time cons...
Keywords: Alkylations, Catalysis, Chemical industry, Cross couplings, PAGE

Professor Product Portal - Baran Group

From our library of Articles, Sigma-Aldrich presents Professor Product Portal - Baran Group
Keywords: Building blocks, Fluorinations, Oxidations, Pharmaceutical

Peer-Reviewed Papers
15

References

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