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793841 Sigma-Aldrich

2,2-Difluoroacetophenone

Synonym: α,α-Difluoroacetophenone, 2,2-Difluoro-1-phenylethanone, Difluoromethyl phenyl ketone

  • CAS Number 395-01-7

  • Empirical Formula (Hill Notation) C8H6F2O

  • Molecular Weight 156.13

  •  MDL number MFCD06246879

  •  PubChem Substance ID 329768421

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Properties

Related Categories Chemical Synthesis, Difluoromethylation, Fluorination Reagents, Synthetic Reagents
Quality Level   100
form   liquid
density   1.180±0.06 g/mL
SMILES string   FC(F)C(C1=CC=CC=C1)=O
InChI   1S/C8H6F2O/c9-8(10)7(11)6-4-2-1-3-5-6/h1-5,8H
InChI key   OLYKCPDTXVZOQF-UHFFFAOYSA-N

Description

Application

Product was reported by Hartwig and coworkers in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides.


Pd-Catalyzed a-Arylation of a;a-Difluoroketones with Aryl Bromides and Chlorides. A Route to Difluoromethylarenes

Packaging

1, 5 g in glass bottle

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
WGK Germany 
WGK 3
Flash Point(F) 
158.0 °F
Flash Point(C) 
70 °C

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Hartwig Group – Professor Product Portal

From our library of Articles, Sigma-Aldrich presents Hartwig Group – Professor Product Portal
Keywords: Aminations, Asymmetric synthesis, Catalysis, Cross couplings, Fluorinations, Hydroaminations, Infrared spectroscopy, Ligands, Oxidations, Silylations, Suzuki reactions

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