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795569 Sigma-Aldrich

Garg 4,5-indolyne precursor

95%

Synonym: 4-(Trimethylsilyl)-1H-indol-5-yl trifluoromethanesulfonate

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Properties

Related Categories Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Pyridyne and Indolyne Precursors
InChI Key   LLCJFYYASDIOJN-UHFFFAOYSA-N
assay   95%
mp   43-48 °C
storage temp.   2-8°C

Description

General description

Garg 4,5-indolyne precursor is an indolyne precursor developed by Professor Neil Garg and coworkers. It is widely used for the synthesis of various N-heterocyclic based compounds. It is also useful for the preparation of substituted indoles (Diels–Alder and azide cycloaddition products).

Application

Indolyne precursor can be activated under mild fluoride conditions, which are highly reactive with dienes and other dipolariphiles (e.g. azides) to provide cycloaddition products containing an indole motif.

Packaging

1 g in glass bottle

Other Notes

Indolyne Experimental and Computational Studies: Synthetic Applications and Origins of Selectivities of Nucleophilic Additions

Regioselective reactions of 3; 4-pyridynes enabled by the aryne distortion model

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
>230 °F
Flash Point(C) 
>110 °C

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles

Articles

Neil Garg Group - Professor Product Portal

From our library of Articles, Sigma-Aldrich presents Neil Garg Group - Professor Product Portal
Keywords: Addition reactions, Building blocks, Catalysis, Cycloadditions, Nucleophilic additions, Pharmaceutical

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