799580 Sigma-Aldrich


Green Alternative


  • CAS Number 1908442-13-6

  • Empirical Formula (Hill Notation) C35H47O3P

  • Molecular Weight 546.72



Related Categories 12 Principles Aligned Products, Catalysis and Inorganic Chemistry, Chemical Synthesis, Greener Alternative Products, Greener Catalysts,
Quality Level   100
assay   ≥95%
form   powder
greener alternative product characteristics   Catalysis
Learn more about the Principles of Green Chemistry.
functional group   phosphine
greener alternative category   Aligned
reaction suitability   reaction type: Buchwald-Hartwig Cross Coupling Reaction
  reaction type: Heck Reaction
  reaction type: Hiyama Coupling
  reaction type: Negishi Coupling
  reaction type: Sonogashira Coupling
  reaction type: Stille Coupling
  reaction type: Suzuki-Miyaura Coupling
  reagent type: ligand
storage temp.   2-8°C
SMILES string   COC(C=CC=C1OC)=[C@]1[C@@]2=C([P@](C(C)(C)C)[C@@H](CC3=C(C(C)C)C=C(C(C)C)C=C3C(C)C)O4)C4=CC=C2



HandaPhos forms a 1:1 complex with Pd(OAc)2 thereby arriving at a pre-catalyst, used at the ppm level, that enables Suzuki-Miyaura cross-couplings to be run under micellar catalysis in water at room temperature. To be used in tandem with Designer Surfactant TPGS-750-M.


25, 100 mg in glass bottle

Other Notes

HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium-Catalyzed Cross-Couplings in Water at Room Temperature

Watch Professor Lipshutz talk about HandaPhos in this webinar:
From milligrams to kilograms: synthetic chemistry following nature′s lead

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