EMAIL THIS PAGE TO A FRIEND
804401 Sigma-Aldrich

PyFluor

Synonym: 2-Pyridinesulfonyl Fluoride

  • CAS Number 878376-35-3

  • Empirical Formula (Hill Notation) C5H4FNO2S

  • Molecular Weight 161.15

  •  MDL number MFCD09265513

  •  PubChem Substance ID 329768867

  •  NACRES NA.22

Purchase

Properties

Related Categories Chemical Synthesis, Fluorination, Fluorination Reagents, Synthetic Reagents
Quality Level   100
assay   95% (HPLC)
form   solid
mp   29-34 °C
storage temp.   2-8°C
SMILES string   O=S(C1=CC=CC=N1)(F)=O
InChI   1S/C5H4FNO2S/c6-10(8,9)5-3-1-2-4-7-5/h1-4H
InChI key   FCFXLXGZHDHJLB-UHFFFAOYSA-N

Description

Application

2-pyridinesulfonyl fluoride can be used for the deoxyfluorination of primary and secondary alcohols in combination with an amidine or guanidine base. In comparison with other common deoxyfluorination reagents, for example, DAST exhibits less elimination side products in direct comparison on certain substrates.

Packaging

5 g in poly bottle

Legal Information

PyFluor: A Low-Cost, Stable, and Selective Deoxyfluorination Reagent

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
RIDADR 
UN 3261 8 / PGII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Abigail Doyle Group – Professor Product Portal

From our library of Articles, Sigma-Aldrich presents Abigail Doyle Group – Professor Product Portal
Keywords: Alkylations, Asymmetric synthesis, Catalysis, Coupling reactions, Cross couplings, Deprotonations, Eliminations, Fluorinations, Ligands, Positron Emission Tomography, Reductive eliminations, Research areas

Deoxyfluorination with 2-Pyridinesulfonyl Fluoride (PyFluor)

The prevalence of organofluorine compounds in industry and drug design necessitates the ability to introduce C–F bonds to molecules. Deoxyfluorination of alcohols is a well-precedented technique for ...
Keywords: Eliminations, Fluorinations, Melting, Purification, Solvents

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?